Abstract
The disease-free probabilities after 3 to 7 years of follow-up of 180 breast cancers of known doubling times were studied to assess the prognostic significance and clinical implications of the growth characteristics of primary breast cancer. Fast-growing tumours, N+ >3, showed a prognosis significantly worse (P <0.01) than that of slow-growing tumours of the same class; no significant differences were found among N- or N+ (1-3) fast-, intermediate- and slow-growing tumours. Highly significant differences were found among fast- and intermediate-growing tumours with different degrees of lymph node involvement (respectively P <0.0001 and P <0.001), with the worst prognosis for N+ >3 tumours. In contrast, no significant differences were found among slow-growing tumours of the different N classes. When the Cox model was applied, the relationship between lymph node involvement and doubling time was significant, as was the interaction term. It is suggested that growth rate and metastatic potential are not the same in primary breast cancers, and their relation should be investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 833-836 |
| Number of pages | 4 |
| Journal | British Journal of Cancer |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Growth rate of primary breast cancer and prognosis : Observations to a 3- to 7-year follow-up in 180 breast cancers. / Galante, E.; Gallus, G.; Guzzon, A.; Bono, A.; Bandieramonte, G.; Di Pietro, S.
In: British Journal of Cancer, Vol. 54, No. 5, 1986, p. 833-836.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth rate of primary breast cancer and prognosis
T2 - Observations to a 3- to 7-year follow-up in 180 breast cancers
AU - Galante, E.
AU - Gallus, G.
AU - Guzzon, A.
AU - Bono, A.
AU - Bandieramonte, G.
AU - Di Pietro, S.
PY - 1986
Y1 - 1986
N2 - The disease-free probabilities after 3 to 7 years of follow-up of 180 breast cancers of known doubling times were studied to assess the prognostic significance and clinical implications of the growth characteristics of primary breast cancer. Fast-growing tumours, N+ >3, showed a prognosis significantly worse (P <0.01) than that of slow-growing tumours of the same class; no significant differences were found among N- or N+ (1-3) fast-, intermediate- and slow-growing tumours. Highly significant differences were found among fast- and intermediate-growing tumours with different degrees of lymph node involvement (respectively P <0.0001 and P <0.001), with the worst prognosis for N+ >3 tumours. In contrast, no significant differences were found among slow-growing tumours of the different N classes. When the Cox model was applied, the relationship between lymph node involvement and doubling time was significant, as was the interaction term. It is suggested that growth rate and metastatic potential are not the same in primary breast cancers, and their relation should be investigated.
AB - The disease-free probabilities after 3 to 7 years of follow-up of 180 breast cancers of known doubling times were studied to assess the prognostic significance and clinical implications of the growth characteristics of primary breast cancer. Fast-growing tumours, N+ >3, showed a prognosis significantly worse (P <0.01) than that of slow-growing tumours of the same class; no significant differences were found among N- or N+ (1-3) fast-, intermediate- and slow-growing tumours. Highly significant differences were found among fast- and intermediate-growing tumours with different degrees of lymph node involvement (respectively P <0.0001 and P <0.001), with the worst prognosis for N+ >3 tumours. In contrast, no significant differences were found among slow-growing tumours of the different N classes. When the Cox model was applied, the relationship between lymph node involvement and doubling time was significant, as was the interaction term. It is suggested that growth rate and metastatic potential are not the same in primary breast cancers, and their relation should be investigated.
UR - http://www.scopus.com/inward/record.url?scp=0022977743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022977743&partnerID=8YFLogxK
U2 - 10.1038/bjc.1986.247
DO - 10.1038/bjc.1986.247
M3 - Article
C2 - 3801276
AN - SCOPUS:0022977743
VL - 54
SP - 833
EP - 836
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 5
ER -