Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment

G. Saggese; S. Bertelloni; G. I. Baroncelli; G. Di Nero; R. Battini

Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment

G. Saggese, S. Bertelloni, G. I. Baroncelli, G. Di Nero, R. Battini

Fondazione Stella Maris

Research output: Contribution to journal › Article › peer-review

Abstract

Growth velocity and serum aminoterminal propeptide of type III procollagen (P-III-NP) were evaluated in 11 girls (age 3.8-8.5 years) with central precocious puberty during luteinizing hormone releasing hormone (LH-RH) analogue treatment (D-Trp⁶-LH-RH, 60 μg/kg im for 28 days, n = 7; Dser(TBU)⁶-LH-RH, 1600 μg/day intranasally, n = 4). Before treatment, growth velocity (10.2 ± 1.9 cm/year) and P-III-NP concentrations (12.8 ± 4.3 μg/l) were in the pubertal range. During therapy, growth velocity significantly decreased to the prepubertal levels. P-III-NP concentrations decreased significantly after six months of therapy (7.9 ± 3.7 μg/l, p <0.001). Three girls with low growth velocity (

Original language	English
Pages (from-to)	261-266
Number of pages	6
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	82
Issue number	3
Publication status	Published - 1993

Keywords

aminoterminal propeptide of type III procollagen
central precocious puberty
growth hormone
growth velocity
LH-RH analogues

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment. / Saggese, G.; Bertelloni, S.; Baroncelli, G. I. et al.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 82, No. 3, 1993, p. 261-266.

Research output: Contribution to journal › Article › peer-review

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abstract = "Growth velocity and serum aminoterminal propeptide of type III procollagen (P-III-NP) were evaluated in 11 girls (age 3.8-8.5 years) with central precocious puberty during luteinizing hormone releasing hormone (LH-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im for 28 days, n = 7; Dser(TBU)6-LH-RH, 1600 μg/day intranasally, n = 4). Before treatment, growth velocity (10.2 ± 1.9 cm/year) and P-III-NP concentrations (12.8 ± 4.3 μg/l) were in the pubertal range. During therapy, growth velocity significantly decreased to the prepubertal levels. P-III-NP concentrations decreased significantly after six months of therapy (7.9 ± 3.7 μg/l, p <0.001). Three girls with low growth velocity (",

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AU - Di Nero, G.

AU - Battini, R.

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N2 - Growth velocity and serum aminoterminal propeptide of type III procollagen (P-III-NP) were evaluated in 11 girls (age 3.8-8.5 years) with central precocious puberty during luteinizing hormone releasing hormone (LH-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im for 28 days, n = 7; Dser(TBU)6-LH-RH, 1600 μg/day intranasally, n = 4). Before treatment, growth velocity (10.2 ± 1.9 cm/year) and P-III-NP concentrations (12.8 ± 4.3 μg/l) were in the pubertal range. During therapy, growth velocity significantly decreased to the prepubertal levels. P-III-NP concentrations decreased significantly after six months of therapy (7.9 ± 3.7 μg/l, p <0.001). Three girls with low growth velocity (

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Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment

Abstract

Keywords

ASJC Scopus subject areas

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