Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment

G. Saggese, S. Bertelloni, G. I. Baroncelli, G. Di Nero, R. Battini

Research output: Contribution to journalArticle

Abstract

Growth velocity and serum aminoterminal propeptide of type III procollagen (P-III-NP) were evaluated in 11 girls (age 3.8-8.5 years) with central precocious puberty during luteinizing hormone releasing hormone (LH-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im for 28 days, n = 7; Dser(TBU)6-LH-RH, 1600 μg/day intranasally, n = 4). Before treatment, growth velocity (10.2 ± 1.9 cm/year) and P-III-NP concentrations (12.8 ± 4.3 μg/l) were in the pubertal range. During therapy, growth velocity significantly decreased to the prepubertal levels. P-III-NP concentrations decreased significantly after six months of therapy (7.9 ± 3.7 μg/l, p <0.001). Three girls with low growth velocity (

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume82
Issue number3
Publication statusPublished - 1993

Keywords

  • aminoterminal propeptide of type III procollagen
  • central precocious puberty
  • growth hormone
  • growth velocity
  • LH-RH analogues

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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