Abstract
Growth velocity and serum aminoterminal propeptide of type III procollagen (P-III-NP) were evaluated in 11 girls (age 3.8-8.5 years) with central precocious puberty during luteinizing hormone releasing hormone (LH-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im for 28 days, n = 7; Dser(TBU)6-LH-RH, 1600 μg/day intranasally, n = 4). Before treatment, growth velocity (10.2 ± 1.9 cm/year) and P-III-NP concentrations (12.8 ± 4.3 μg/l) were in the pubertal range. During therapy, growth velocity significantly decreased to the prepubertal levels. P-III-NP concentrations decreased significantly after six months of therapy (7.9 ± 3.7 μg/l, p <0.001). Three girls with low growth velocity (
| Original language | English |
|---|---|
| Pages (from-to) | 261-266 |
| Number of pages | 6 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 82 |
| Issue number | 3 |
| Publication status | Published - 1993 |
Keywords
- aminoterminal propeptide of type III procollagen
- central precocious puberty
- growth hormone
- growth velocity
- LH-RH analogues
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Saggese, G., Bertelloni, S., Baroncelli, G. I., Di Nero, G., & Battini, R. (1993). Growth velocity and serum aminoterminal propeptide of type III procollagen in precocious puberty during gonadotropin-releasing hormone analogue treatment. Acta Paediatrica, International Journal of Paediatrics, 82(3), 261-266.