GSTM1 and GSTT1 copy numbers and mRNA expression in lung cancer

Melissa Rotunno, Tram K. Lam, Aurelie Vogt, Pier Alberto Bertazzi, Jay H. Lubin, Neil E. Caporaso, Maria Teresa Landi

Research output: Contribution to journalArticle

Abstract

Large fractions of the human population do not express GSTM1 and GSTT1 (GSTM1/T1) enzymes because of deletions in these genes. These variations affect xenobiotic metabolism and have been evaluated in relation to lung cancer risk, mostly based on null/present gene models. We measured GSTM1/T1 heterozygous deletions, not tested in genome-wide association studies, in 2,120 controls and 2,100 cases from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. We evaluated their effect on mRNA expression on lung tissue and peripheral blood samples and their association with lung cancer risk overall and by histology types. We tested the null/present, dominant, and additive models using logistic regression. Cigarette smoking and gender were studied as possible modifiers. Gene expression from blood and lung tissue cells was strongly down regulated in subjects carrying GSTM1/T1 deletions by both trend and dominant models (P

Original languageEnglish
JournalMolecular Carcinogenesis
Volume51
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Copy numbers
  • Gene expression
  • GST
  • Lung cancer
  • Smoking and gender differences

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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  • Cite this

    Rotunno, M., Lam, T. K., Vogt, A., Bertazzi, P. A., Lubin, J. H., Caporaso, N. E., & Landi, M. T. (2012). GSTM1 and GSTT1 copy numbers and mRNA expression in lung cancer. Molecular Carcinogenesis, 51(SUPPL. 1). https://doi.org/10.1002/mc.21890