GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients

Sara Piacentini, Renato Polimanti, Rosanna Squitti, Mariacarla Ventriglia, Emanuele Cassetta, Fabrizio Vernieri, Paolo Maria Rossini, Dario Manfellotto, Maria Fuciarelli

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly. The causes of AD are very complex but there is general agreement about the existence of a link between Alzheimer's disease and oxidative stress. The Glutathione S-transferases (GSTs) act to detoxify products of oxidation that cause damage to macromolecules. Particular attention has been focused on GST genes because polymorphisms are important determinants of disease risk. To evaluate if GSTA1, GSTM1, GSTP1, and GSTT1 genes are associated with LOAD we screened a case-control population (n = 311). Differences in genotype distributions between AD patients and controls were found only for the GSTM1 null genotype (P <0.001). In addition, a logistic regression analysis also conferred a positive association between the GSTM1 null genotype and LOAD after adjustment for age and gender (OR = 2.09; 95%CI = 1.31-3.35). The GSTM1 enzyme detoxifies substances such as exogenous and endogenous metabolites and plays a regulatory role in cellular signaling. Previous studies have highlighted that GSTM1 has a role in neurodegenerative disorders, but no data have associated the GSTM1 gene with AD risk. Our outcome suggests that the GSTM1 null genotype is a risk factor for AD in Italian patients.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalJournal of the Neurological Sciences
Volume317
Issue number1-2
DOIs
Publication statusPublished - Jun 15 2012

Fingerprint

Alzheimer Disease
Genotype
Glutathione Transferase
Genes
Neurodegenerative Diseases
Dementia
Oxidative Stress
Logistic Models
Regression Analysis
Enzymes
Population

Keywords

  • Detoxification enzymes
  • Genetic polymorphism
  • Glutatione S-transferases
  • Late-onset Alzheimer's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Piacentini, S., Polimanti, R., Squitti, R., Ventriglia, M., Cassetta, E., Vernieri, F., ... Fuciarelli, M. (2012). GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. Journal of the Neurological Sciences, 317(1-2), 137-140. https://doi.org/10.1016/j.jns.2012.01.026

GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. / Piacentini, Sara; Polimanti, Renato; Squitti, Rosanna; Ventriglia, Mariacarla; Cassetta, Emanuele; Vernieri, Fabrizio; Rossini, Paolo Maria; Manfellotto, Dario; Fuciarelli, Maria.

In: Journal of the Neurological Sciences, Vol. 317, No. 1-2, 15.06.2012, p. 137-140.

Research output: Contribution to journalArticle

Piacentini, S, Polimanti, R, Squitti, R, Ventriglia, M, Cassetta, E, Vernieri, F, Rossini, PM, Manfellotto, D & Fuciarelli, M 2012, 'GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients', Journal of the Neurological Sciences, vol. 317, no. 1-2, pp. 137-140. https://doi.org/10.1016/j.jns.2012.01.026
Piacentini S, Polimanti R, Squitti R, Ventriglia M, Cassetta E, Vernieri F et al. GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. Journal of the Neurological Sciences. 2012 Jun 15;317(1-2):137-140. https://doi.org/10.1016/j.jns.2012.01.026
Piacentini, Sara ; Polimanti, Renato ; Squitti, Rosanna ; Ventriglia, Mariacarla ; Cassetta, Emanuele ; Vernieri, Fabrizio ; Rossini, Paolo Maria ; Manfellotto, Dario ; Fuciarelli, Maria. / GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients. In: Journal of the Neurological Sciences. 2012 ; Vol. 317, No. 1-2. pp. 137-140.
@article{4450bf20157b4ffe9e8dd3946eac4f03,
title = "GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients",
abstract = "Alzheimer's disease (AD) is the most common form of dementia in the elderly. The causes of AD are very complex but there is general agreement about the existence of a link between Alzheimer's disease and oxidative stress. The Glutathione S-transferases (GSTs) act to detoxify products of oxidation that cause damage to macromolecules. Particular attention has been focused on GST genes because polymorphisms are important determinants of disease risk. To evaluate if GSTA1, GSTM1, GSTP1, and GSTT1 genes are associated with LOAD we screened a case-control population (n = 311). Differences in genotype distributions between AD patients and controls were found only for the GSTM1 null genotype (P <0.001). In addition, a logistic regression analysis also conferred a positive association between the GSTM1 null genotype and LOAD after adjustment for age and gender (OR = 2.09; 95{\%}CI = 1.31-3.35). The GSTM1 enzyme detoxifies substances such as exogenous and endogenous metabolites and plays a regulatory role in cellular signaling. Previous studies have highlighted that GSTM1 has a role in neurodegenerative disorders, but no data have associated the GSTM1 gene with AD risk. Our outcome suggests that the GSTM1 null genotype is a risk factor for AD in Italian patients.",
keywords = "Detoxification enzymes, Genetic polymorphism, Glutatione S-transferases, Late-onset Alzheimer's disease",
author = "Sara Piacentini and Renato Polimanti and Rosanna Squitti and Mariacarla Ventriglia and Emanuele Cassetta and Fabrizio Vernieri and Rossini, {Paolo Maria} and Dario Manfellotto and Maria Fuciarelli",
year = "2012",
month = "6",
day = "15",
doi = "10.1016/j.jns.2012.01.026",
language = "English",
volume = "317",
pages = "137--140",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients

AU - Piacentini, Sara

AU - Polimanti, Renato

AU - Squitti, Rosanna

AU - Ventriglia, Mariacarla

AU - Cassetta, Emanuele

AU - Vernieri, Fabrizio

AU - Rossini, Paolo Maria

AU - Manfellotto, Dario

AU - Fuciarelli, Maria

PY - 2012/6/15

Y1 - 2012/6/15

N2 - Alzheimer's disease (AD) is the most common form of dementia in the elderly. The causes of AD are very complex but there is general agreement about the existence of a link between Alzheimer's disease and oxidative stress. The Glutathione S-transferases (GSTs) act to detoxify products of oxidation that cause damage to macromolecules. Particular attention has been focused on GST genes because polymorphisms are important determinants of disease risk. To evaluate if GSTA1, GSTM1, GSTP1, and GSTT1 genes are associated with LOAD we screened a case-control population (n = 311). Differences in genotype distributions between AD patients and controls were found only for the GSTM1 null genotype (P <0.001). In addition, a logistic regression analysis also conferred a positive association between the GSTM1 null genotype and LOAD after adjustment for age and gender (OR = 2.09; 95%CI = 1.31-3.35). The GSTM1 enzyme detoxifies substances such as exogenous and endogenous metabolites and plays a regulatory role in cellular signaling. Previous studies have highlighted that GSTM1 has a role in neurodegenerative disorders, but no data have associated the GSTM1 gene with AD risk. Our outcome suggests that the GSTM1 null genotype is a risk factor for AD in Italian patients.

AB - Alzheimer's disease (AD) is the most common form of dementia in the elderly. The causes of AD are very complex but there is general agreement about the existence of a link between Alzheimer's disease and oxidative stress. The Glutathione S-transferases (GSTs) act to detoxify products of oxidation that cause damage to macromolecules. Particular attention has been focused on GST genes because polymorphisms are important determinants of disease risk. To evaluate if GSTA1, GSTM1, GSTP1, and GSTT1 genes are associated with LOAD we screened a case-control population (n = 311). Differences in genotype distributions between AD patients and controls were found only for the GSTM1 null genotype (P <0.001). In addition, a logistic regression analysis also conferred a positive association between the GSTM1 null genotype and LOAD after adjustment for age and gender (OR = 2.09; 95%CI = 1.31-3.35). The GSTM1 enzyme detoxifies substances such as exogenous and endogenous metabolites and plays a regulatory role in cellular signaling. Previous studies have highlighted that GSTM1 has a role in neurodegenerative disorders, but no data have associated the GSTM1 gene with AD risk. Our outcome suggests that the GSTM1 null genotype is a risk factor for AD in Italian patients.

KW - Detoxification enzymes

KW - Genetic polymorphism

KW - Glutatione S-transferases

KW - Late-onset Alzheimer's disease

UR - http://www.scopus.com/inward/record.url?scp=84860283883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860283883&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2012.01.026

DO - 10.1016/j.jns.2012.01.026

M3 - Article

C2 - 22381228

AN - SCOPUS:84860283883

VL - 317

SP - 137

EP - 140

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -