GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

Claudia A. Landis, Susan B. Masters, Anna Spada, Ann M. Pace, Henry R. Bourne, Lucia Vallar

Research output: Contribution to journalArticle

Abstract

A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs. The resulting activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone. Amino acids substituted in the putative gsp oncogene identify a domain of G protein α-chains required for intrinsic ability to hydrolyse GTP. This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras.

Original languageEnglish
Pages (from-to)692-696
Number of pages5
JournalNature
Volume340
Issue number6236
Publication statusPublished - 1989

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    Landis, C. A., Masters, S. B., Spada, A., Pace, A. M., Bourne, H. R., & Vallar, L. (1989). GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature, 340(6236), 692-696.