Guanidine hydrochloride in infantile and juvenile spinal muscular atrophy. A double blind controlled study

C. Angelini, G. F. Micaglio, C. Trevisan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A double-blind controlled study was conducted to assess the effect of guanidine hydrochloride on infantile and juvenile spinal muscular atrophy. Twenty patients (twelve treated with guanidine and eight given placebo) were followed up for up to one year, and muscular strength was evaluated by manual muscle testing. The most frequent side effects of the drug were paraesthesiae and anaemia. In all our five patients affected by infantile spinal muscular atrophy with prolonged survival, guanidine treatment resulted in a clinical stabilization. No effect was observed in the Kugelberg-Welander group.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalActa Neurologica
Volume35
Issue number6
Publication statusPublished - 1980

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Spinal Muscular Atrophies of Childhood
Guanidine
Double-Blind Method
Paresthesia
Drug-Related Side Effects and Adverse Reactions
Anemia
Placebos
Muscles
Survival
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Guanidine hydrochloride in infantile and juvenile spinal muscular atrophy. A double blind controlled study. / Angelini, C.; Micaglio, G. F.; Trevisan, C.

In: Acta Neurologica, Vol. 35, No. 6, 1980, p. 460-465.

Research output: Contribution to journalArticle

Angelini, C. ; Micaglio, G. F. ; Trevisan, C. / Guanidine hydrochloride in infantile and juvenile spinal muscular atrophy. A double blind controlled study. In: Acta Neurologica. 1980 ; Vol. 35, No. 6. pp. 460-465.
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