Guanylate cyclase in human brain tumors: Regulation of cellular growth

K. Kumakura, L. Frattola, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


Guanylate cyclase activity measured in different brain tumors has been found higher in meningiomas and oligodendrogliomas in comparison with normal cortex. The apparent Km of GTP for guanylate cyclase is considerably lower in all tumor tested in comparison to normal cortex. The data may be in line with the assumption that cGMP is one of the intracellular mediators triggering cell growth.

Original languageEnglish
Pages (from-to)579-586
Number of pages8
JournalPharmacological Research Communications
Issue number6
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology


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