TY - JOUR
T1 - Guidelines for preclinical animal research in ALS/MND
T2 - A consensus meeting
AU - Ludolph, Albert C.
AU - Bendotti, Caterina
AU - Blaugrund, Eran
AU - Chio, Adriano
AU - Greensmith, Linda
AU - Loeffler, Jean Philippe
AU - Mead, Richard
AU - Niessen, Heiko G.
AU - Petri, Susanne
AU - Pradat, Pierre Francois
AU - Robberecht, Wim
AU - Ruegg, Markus
AU - Schwalenstcker, Birgit
AU - Stiller, Detlev
AU - Van Den Berg, Leonard
AU - Vieira, Fernando
AU - Von Horsten, Stephan
PY - 2010
Y1 - 2010
N2 - The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.
AB - The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.
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U2 - 10.3109/17482960903545334
DO - 10.3109/17482960903545334
M3 - Article
C2 - 20184514
AN - SCOPUS:77649285022
VL - 11
SP - 38
EP - 45
JO - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
SN - 1466-0822
IS - 1-2
ER -