Guidelines for preclinical animal research in ALS/MND: A consensus meeting

Albert C. Ludolph, Caterina Bendotti, Eran Blaugrund, Adriano Chio, Linda Greensmith, Jean Philippe Loeffler, Richard Mead, Heiko G. Niessen, Susanne Petri, Pierre Francois Pradat, Wim Robberecht, Markus Ruegg, Birgit Schwalenstcker, Detlev Stiller, Leonard Van Den Berg, Fernando Vieira, Stephan Von Horsten

Research output: Contribution to journalArticlepeer-review

Abstract

The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalAmyotrophic Lateral Sclerosis
Volume11
Issue number1-2
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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