Guidelines for the Clinical Use of Albumin: Comparison of Use in Two Italian Hospitals and a Third Hospital Without Guidelines

Antonietta Martelli, Paolo Strada, Ildefonso Cagliani, Giovanni Brambilla

Research output: Contribution to journalArticle

Abstract

Background: In the absence of clinical practice guidelines prior to 1999, the consumption of human albumin in the Liguria region of Italy was very high, despite possible adverse effects, limited supply, and significant cost. Objective: The purpose of this study was to assess the impact of comprehensive guidelines on the amount of albumin used in 2 general hospitals and to compare it with that of a third general hospital that did not adopt the guidelines. Methods: We analyzed the influence of the guidelines on albumin use in 2 general hospitals (hospitals 1 and 2) in the Liguria region by comparing albumin consumption during the year before the distribution of the guidelines (1999) with consumption in the 2 years after their distribution (2000 and 2001). We compared these data with those of a third general hospital that did not adopt the guidelines (hospital 3). The parameters considered were total consumption of albumin, consumption per bed, consumption per hospital stay, mean time to discharge, expenditure per bed, and mortality rate. Results: In the years 2000 and 2001, the adoption of guidelines reduced albumin consumption in hospitals 1 and 2. In hospital 1, where the release of albumin was carefully controlled by the transfusion service, albumin use per hospital stay decreased 8.7% in 2000 and 7.6% in 2001 from 1999; in hospital 2, use decreased 73.8% and 77.4%, respectively, from 1999. In hospital 3, rejection of the guidelines was coupled with an increase of 2.9% and 8.4%, respectively, in the amount of albumin used per hospital stay. In the years 2000 and 2001, the savings in the expenditure for albumin was ∼17,000 euro in hospital 1 and ∼200,000 euro in hospital 2. Conclusion: This study confirms that the adoption of guidelines may substantially reduce the inappropriate use of albumin and relative costs.

Original languageEnglish
Pages (from-to)676-684
Number of pages9
JournalCurrent Therapeutic Research
Volume64
Issue number9
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Clinical use of albumin
  • Efficacy of guideline application
  • Guidelines

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Guidelines for the Clinical Use of Albumin: Comparison of Use in Two Italian Hospitals and a Third Hospital Without Guidelines'. Together they form a unique fingerprint.

  • Cite this