Guidelines for the diagnosis and treatment of hyperprolactinemia

B. M K Biller, A. Luciano, P. G. Crosignani, M. Molitch, D. Olive, R. Rebar, J. Sanfilippo, J. Webster, H. Zacur

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperprolactinemia is the most common endocrine disorder of the hypothalamic-pituitary axis. While it can occur in men, it occurs more commonly in women. The prevalence of hyperprolactinemia ranges from 0.4% in an unselected normal adult population to as high as 9-17% in women with reproductive disorders. There are many possible causes of hyperprolactinemia, falling into three general categories: physiologic, pharmacologic and pathologic. When specific treatable underlying causes have been eliminated and in cases of severe hyperprolactinemia, the most likely cause is a prolactin (PRL)-secreting pituitary adenoma. Microadenomas should be treated medically, with a dopamine agonist, if there is an indication for therapy (such as amenorrhea, infertility or bothersome galactorrhea). If there is no treatment of hyperprolactinemia are bromocriptine and cabergoline. Bromocriptine is usually given once or twice daily, while cabergoline has a long duration of action and is given once or twice weekly. Results of comparative studies indicate that cabergoline is clearly superior to bromocriptine in efficacy (PRL suppression, restoration of gonadal function) and tolerability.

Original languageEnglish
Pages (from-to)1075-1084
Number of pages10
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume44
Issue number12 SUPPL.
Publication statusPublished - 1999

Keywords

  • Bromocriptine
  • Cabergoline
  • Dopamine agonists
  • Prolactinemia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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