Linee guida per la gestione dei versamenti pleurici durante il trattamento con dasatinib nel-la leucemia mieloide cronica

Translated title of the contribution: Guidelines for the management of pleural effusions during dasatinib treatment in chronic myeloid leukemia

Massimo Breccia, Luigiana Luciano, Alessandra Iurlo, Fabio Stagno, Matteo Molica, Antonella Gozzini, Giuseppe Saglio, Giuliana Alimena

Research output: Contribution to journalArticle

Abstract

Dasatinib is indicated for chronic myeloid leukemia (CML) patients with resistance or intolerance to imatinib or as a frst line therapy in chronic or blastic phase of the disease; it has 325-fold increase potency compared to imatinib and is active in mutated and unmutated resistant patients. Pleural effusions are therapy-related events that can occur in all subset of patients treated with this drug. Aim of this paper is to draw up clinical guidelines on the management of pleural effusions associated with dasatinib treatment. Recommendations are based upon the published data and clinical personal experience from a number of different centres. Incidence of pleural effusions in different dasatinib trials, the related pathogenetic mechanisms and the associated risk factors are discussed. Practical recommendations to manage pleural effusions were fnally composed. Adequate monitoring of patients with predisposing factors is necessary in order to early identify subjects at risk of developing such complications as well as to correctly manage them.

Translated title of the contributionGuidelines for the management of pleural effusions during dasatinib treatment in chronic myeloid leukemia
Original languageItalian
Pages (from-to)121-129
Number of pages9
JournalEuropean Journal of Oncology
Volume19
Issue number3
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Oncology

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    Breccia, M., Luciano, L., Iurlo, A., Stagno, F., Molica, M., Gozzini, A., Saglio, G., & Alimena, G. (2014). Linee guida per la gestione dei versamenti pleurici durante il trattamento con dasatinib nel-la leucemia mieloide cronica. European Journal of Oncology, 19(3), 121-129.