Linee guida su prevenzione e trattamento dell'ipovitaminosi D con colecalciferolo

Translated title of the contribution: Guidelines on prevention and treatment of vitamin D deficiency

S. Adami, E. Romagnoli, V. Carnevale, A. Scillitani, A. Giusti, M. Rossini, D. Gatti, R. Nuti, S. Minisola

Research output: Contribution to journalArticle

Abstract

The Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS) has elaborated the following guidelines about the definition, prevention and treatment of inadequate vitamin D status. The highlights are presented here. • Daily vitamin D allowance ranges from 1,500 IU (healthy adults) to 2,300 IU (elderly with low calcium intake). Since the average Italian diet includes around 300 IU/day, subjects with no effective sun exposure should be supplemented with 1,200-2,000 IU vitamin D per day. • The serum 25-hydroxy-vitamin D [25(OH)D] levels represents the most accurate way to assess vitamin D repletion, even though there are still no standardized assay methods. • Conditions of "deficiency" and "insufficiency" are defined by the following ranges of 25(OH)D levels: less than 20 ng/ml and 20-30 ng/ml, respectively. • In Italy, approximately 50% of young healthy subjects have vitamin D insufficiency during the winter months. The prevalence of deficiency increases with ageing, affecting almost all elderly subjects not on vitamin D supplements. • When a condition of deficiency has been identified, a cumulative dose of 300,000-1,000,000 IU, over 1-4 weeks is recommended. • In subjects recently treated for deficiency-insufficiency, a maintenance dose of 800-2,000 IU/day (or weekly equivalent) is recommended. In patients on daily doses over 1,000 IU, 25(OH)D levels should be checked regularly (e.g. once every two years). • The highest tolerated daily dose has been identified as 4,000 IU/day. • Vitamin D supplementation should be carefully monitored in patients at higher risk of vitamin D intoxication (granulomatosis) or with primary hyperparathyroidism. • In pregnant women, vitamin D supplements should be given as in non-pregnant women, but bolus administration (i.e.: single dose >25,000 IU) should be avoided.

Original languageItalian
Pages (from-to)129-147
Number of pages19
JournalReumatismo
Volume63
Issue number3
Publication statusPublished - 2011

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Vitamin D Deficiency
Vitamin D
Guidelines
Therapeutics
Primary Hyperparathyroidism
Bone Diseases
Solar System
Italy
Osteoporosis
Minerals
Pregnant Women
Healthy Volunteers
Diet
Calcium

ASJC Scopus subject areas

  • Rheumatology

Cite this

Adami, S., Romagnoli, E., Carnevale, V., Scillitani, A., Giusti, A., Rossini, M., ... Minisola, S. (2011). Linee guida su prevenzione e trattamento dell'ipovitaminosi D con colecalciferolo. Reumatismo, 63(3), 129-147.

Linee guida su prevenzione e trattamento dell'ipovitaminosi D con colecalciferolo. / Adami, S.; Romagnoli, E.; Carnevale, V.; Scillitani, A.; Giusti, A.; Rossini, M.; Gatti, D.; Nuti, R.; Minisola, S.

In: Reumatismo, Vol. 63, No. 3, 2011, p. 129-147.

Research output: Contribution to journalArticle

Adami, S, Romagnoli, E, Carnevale, V, Scillitani, A, Giusti, A, Rossini, M, Gatti, D, Nuti, R & Minisola, S 2011, 'Linee guida su prevenzione e trattamento dell'ipovitaminosi D con colecalciferolo', Reumatismo, vol. 63, no. 3, pp. 129-147.
Adami, S. ; Romagnoli, E. ; Carnevale, V. ; Scillitani, A. ; Giusti, A. ; Rossini, M. ; Gatti, D. ; Nuti, R. ; Minisola, S. / Linee guida su prevenzione e trattamento dell'ipovitaminosi D con colecalciferolo. In: Reumatismo. 2011 ; Vol. 63, No. 3. pp. 129-147.
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