Abstract
Background: Guidewire (GW) cannulation can reduce the risk of post-ERCP pancreatitis (PEP) by avoiding the opacification of the main pancreatic duct. Objective: To compare the effects of conventional contrast ERCP and GW cannulation of the common bile duct on the rate of PEP in low- and high-risk patients. Design: Prospective, comparative-intervention single-center study. Setting: Tertiary referral center. Patients: Patients with biliary disease with an intact papilla were prospectively examined by ERCP. Interventions: Biliary cannulation using a sphincterotome with contrast injection (ConI) or a hydrophilic GW without contrast injection. Main Outcome Measurements: Pancreatitis rate in the GW group and the contrast injection (ConI) group. Results: PEP occurred in 60 of 1249 patients (4.8%), 35 of 678 (5.2%) in the GW group and 25 of 571 (4.4%) in the ConI group (not significant). The overall rate of PEP was significantly higher in high-risk patients (12.2%) than in low-risk patients (3.5%) (P
Original language | English |
---|---|
Pages (from-to) | 339-346 |
Number of pages | 8 |
Journal | Gastrointestinal Endoscopy |
Volume | 75 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2012 |
Keywords
- acute recurrent pancreatitis
- ARP
- CBD
- CI
- common bile duct
- confidence interval
- ConI
- contrast injection
- guidewire
- GW
- main pancreatic duct
- MPD
- PEP
- post-ERCP pancreatitis
- SOD
- sphincter of Oddi dysfunction
ASJC Scopus subject areas
- Gastroenterology
- Radiology Nuclear Medicine and imaging