Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper

Gregor Thut, Til Ole Bergmann, Flavio Fröhlich, Surjo R. Soekadar, John Stuart Brittain, Antoni Valero-Cabré, Alexander T. Sack, Carlo Miniussi, Andrea Antal, Hartwig Roman Siebner, Ulf Ziemann, Christoph S. Herrmann

Research output: Contribution to journalReview article

Abstract

Non-invasive transcranial brain stimulation (NTBS) techniques have a wide range of applications but also suffer from a number of limitations mainly related to poor specificity of intervention and variable effect size. These limitations motivated recent efforts to focus on the temporal dimension of NTBS with respect to the ongoing brain activity. Temporal patterns of ongoing neuronal activity, in particular brain oscillations and their fluctuations, can be traced with electro- or magnetoencephalography (EEG/MEG), to guide the timing as well as the stimulation settings of NTBS. These novel, online and offline EEG/MEG-guided NTBS-approaches are tailored to specifically interact with the underlying brain activity. Online EEG/MEG has been used to guide the timing of NTBS (i.e., when to stimulate): by taking into account instantaneous phase or power of oscillatory brain activity, NTBS can be aligned to fluctuations in excitability states. Moreover, offline EEG/MEG recordings prior to interventions can inform researchers and clinicians how to stimulate: by frequency-tuning NTBS to the oscillation of interest, intrinsic brain oscillations can be up- or down-regulated. In this paper, we provide an overview of existing approaches and ideas of EEG/MEG-guided interventions, and their promises and caveats. We point out potential future lines of research to address challenges.

Original languageEnglish
Pages (from-to)843-857
Number of pages15
JournalClinical Neurophysiology
Volume128
Issue number5
DOIs
Publication statusPublished - 2017

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Keywords

  • Brain oscillations
  • Electroencephalography
  • Magnetoencephalography
  • Non-invasive transcranial brain stimulation (NTBS)
  • Temporally guided NTBS

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Thut, G., Bergmann, T. O., Fröhlich, F., Soekadar, S. R., Brittain, J. S., Valero-Cabré, A., Sack, A. T., Miniussi, C., Antal, A., Siebner, H. R., Ziemann, U., & Herrmann, C. S. (2017). Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper. Clinical Neurophysiology, 128(5), 843-857. https://doi.org/10.1016/j.clinph.2017.01.003