Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey

Adriano Chiò, D. Cocito, M. Leone, M. T. Giordana, G. Mora, R. Mutani, A. Calvo, N. Di Vito, M. Vercellino, A. Bertolotto, E. Bottacchi, L. Mazzini, A. A. Terreni, D. Schiffer, B. Bergamasco, I. Rainero, A. Tribolo, R. Sciolla, F. Mondino, P. GavianiF. Monaco, M. De Mattei, E. Morgando, L. Sosso, M. Gionco, U. Morino, M. Nobili, L. Appendino, D. Piazza, E. Oddenino, W. Liboni, G. Vaula, G. Ferrari, M. Favero, C. Doriguzzi Bozzo, P. Santamaria, U. Massazza, E. Bollani, A. Villani, R. Conti, C. Balzarini, M. Palermo, F. Vergnano, S. Cordera, C. Buffa, M. T. Penza, F. Fassio, P. Meineri, A. Cognazzo, C. Mocellini, A. Dutto, A. Cucatto, C. Cavestro, W. Troni, G. Corso

Research output: Contribution to journalArticle

Abstract

Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

Original languageEnglish
Pages (from-to)1146-1150
Number of pages5
JournalNeurology
Volume60
Issue number7
Publication statusPublished - Apr 8 2003

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Incidence
Population
Respiratory Care Units
National Institute of Neurological Disorders and Stroke
Communication Disorders
Social Adjustment
Mortality
Respiratory Tract Infections
Intensive Care Units
Surveys and Questionnaires
Multivariate Analysis

ASJC Scopus subject areas

  • Neuroscience(all)

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Chiò, A., Cocito, D., Leone, M., Giordana, M. T., Mora, G., Mutani, R., ... Corso, G. (2003). Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey. Neurology, 60(7), 1146-1150.

Guillain-Barré syndrome : A prospective, population-based incidence and outcome survey. / Chiò, Adriano; Cocito, D.; Leone, M.; Giordana, M. T.; Mora, G.; Mutani, R.; Calvo, A.; Di Vito, N.; Vercellino, M.; Bertolotto, A.; Bottacchi, E.; Mazzini, L.; Terreni, A. A.; Schiffer, D.; Bergamasco, B.; Rainero, I.; Tribolo, A.; Sciolla, R.; Mondino, F.; Gaviani, P.; Monaco, F.; De Mattei, M.; Morgando, E.; Sosso, L.; Gionco, M.; Morino, U.; Nobili, M.; Appendino, L.; Piazza, D.; Oddenino, E.; Liboni, W.; Vaula, G.; Ferrari, G.; Favero, M.; Doriguzzi Bozzo, C.; Santamaria, P.; Massazza, U.; Bollani, E.; Villani, A.; Conti, R.; Balzarini, C.; Palermo, M.; Vergnano, F.; Cordera, S.; Buffa, C.; Penza, M. T.; Fassio, F.; Meineri, P.; Cognazzo, A.; Mocellini, C.; Dutto, A.; Cucatto, A.; Cavestro, C.; Troni, W.; Corso, G.

In: Neurology, Vol. 60, No. 7, 08.04.2003, p. 1146-1150.

Research output: Contribution to journalArticle

Chiò, A, Cocito, D, Leone, M, Giordana, MT, Mora, G, Mutani, R, Calvo, A, Di Vito, N, Vercellino, M, Bertolotto, A, Bottacchi, E, Mazzini, L, Terreni, AA, Schiffer, D, Bergamasco, B, Rainero, I, Tribolo, A, Sciolla, R, Mondino, F, Gaviani, P, Monaco, F, De Mattei, M, Morgando, E, Sosso, L, Gionco, M, Morino, U, Nobili, M, Appendino, L, Piazza, D, Oddenino, E, Liboni, W, Vaula, G, Ferrari, G, Favero, M, Doriguzzi Bozzo, C, Santamaria, P, Massazza, U, Bollani, E, Villani, A, Conti, R, Balzarini, C, Palermo, M, Vergnano, F, Cordera, S, Buffa, C, Penza, MT, Fassio, F, Meineri, P, Cognazzo, A, Mocellini, C, Dutto, A, Cucatto, A, Cavestro, C, Troni, W & Corso, G 2003, 'Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey', Neurology, vol. 60, no. 7, pp. 1146-1150.
Chiò A, Cocito D, Leone M, Giordana MT, Mora G, Mutani R et al. Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey. Neurology. 2003 Apr 8;60(7):1146-1150.
Chiò, Adriano ; Cocito, D. ; Leone, M. ; Giordana, M. T. ; Mora, G. ; Mutani, R. ; Calvo, A. ; Di Vito, N. ; Vercellino, M. ; Bertolotto, A. ; Bottacchi, E. ; Mazzini, L. ; Terreni, A. A. ; Schiffer, D. ; Bergamasco, B. ; Rainero, I. ; Tribolo, A. ; Sciolla, R. ; Mondino, F. ; Gaviani, P. ; Monaco, F. ; De Mattei, M. ; Morgando, E. ; Sosso, L. ; Gionco, M. ; Morino, U. ; Nobili, M. ; Appendino, L. ; Piazza, D. ; Oddenino, E. ; Liboni, W. ; Vaula, G. ; Ferrari, G. ; Favero, M. ; Doriguzzi Bozzo, C. ; Santamaria, P. ; Massazza, U. ; Bollani, E. ; Villani, A. ; Conti, R. ; Balzarini, C. ; Palermo, M. ; Vergnano, F. ; Cordera, S. ; Buffa, C. ; Penza, M. T. ; Fassio, F. ; Meineri, P. ; Cognazzo, A. ; Mocellini, C. ; Dutto, A. ; Cucatto, A. ; Cavestro, C. ; Troni, W. ; Corso, G. / Guillain-Barré syndrome : A prospective, population-based incidence and outcome survey. In: Neurology. 2003 ; Vol. 60, No. 7. pp. 1146-1150.
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abstract = "Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barr{\'e} syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95{\%} CI, 1.13 to 1.63). A total of 7 (5.8{\%}) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.",
author = "Adriano Chi{\`o} and D. Cocito and M. Leone and Giordana, {M. T.} and G. Mora and R. Mutani and A. Calvo and {Di Vito}, N. and M. Vercellino and A. Bertolotto and E. Bottacchi and L. Mazzini and Terreni, {A. A.} and D. Schiffer and B. Bergamasco and I. Rainero and A. Tribolo and R. Sciolla and F. Mondino and P. Gaviani and F. Monaco and {De Mattei}, M. and E. Morgando and L. Sosso and M. Gionco and U. Morino and M. Nobili and L. Appendino and D. Piazza and E. Oddenino and W. Liboni and G. Vaula and G. Ferrari and M. Favero and {Doriguzzi Bozzo}, C. and P. Santamaria and U. Massazza and E. Bollani and A. Villani and R. Conti and C. Balzarini and M. Palermo and F. Vergnano and S. Cordera and C. Buffa and Penza, {M. T.} and F. Fassio and P. Meineri and A. Cognazzo and C. Mocellini and A. Dutto and A. Cucatto and C. Cavestro and W. Troni and G. Corso",
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TY - JOUR

T1 - Guillain-Barré syndrome

T2 - A prospective, population-based incidence and outcome survey

AU - Chiò, Adriano

AU - Cocito, D.

AU - Leone, M.

AU - Giordana, M. T.

AU - Mora, G.

AU - Mutani, R.

AU - Calvo, A.

AU - Di Vito, N.

AU - Vercellino, M.

AU - Bertolotto, A.

AU - Bottacchi, E.

AU - Mazzini, L.

AU - Terreni, A. A.

AU - Schiffer, D.

AU - Bergamasco, B.

AU - Rainero, I.

AU - Tribolo, A.

AU - Sciolla, R.

AU - Mondino, F.

AU - Gaviani, P.

AU - Monaco, F.

AU - De Mattei, M.

AU - Morgando, E.

AU - Sosso, L.

AU - Gionco, M.

AU - Morino, U.

AU - Nobili, M.

AU - Appendino, L.

AU - Piazza, D.

AU - Oddenino, E.

AU - Liboni, W.

AU - Vaula, G.

AU - Ferrari, G.

AU - Favero, M.

AU - Doriguzzi Bozzo, C.

AU - Santamaria, P.

AU - Massazza, U.

AU - Bollani, E.

AU - Villani, A.

AU - Conti, R.

AU - Balzarini, C.

AU - Palermo, M.

AU - Vergnano, F.

AU - Cordera, S.

AU - Buffa, C.

AU - Penza, M. T.

AU - Fassio, F.

AU - Meineri, P.

AU - Cognazzo, A.

AU - Mocellini, C.

AU - Dutto, A.

AU - Cucatto, A.

AU - Cavestro, C.

AU - Troni, W.

AU - Corso, G.

PY - 2003/4/8

Y1 - 2003/4/8

N2 - Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

AB - Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

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C2 - 12682322

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