Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?

Research output: Contribution to journalArticle

Abstract

Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammatory pattern would have sustained the pathophysiologic mechanism of this immune neuropathy.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalClinical Neurology and Neurosurgery
Volume173
DOIs
Publication statusPublished - Oct 1 2018

Keywords

  • Acute demyelinating polyneuropathy
  • Guillain-Barré syndrome
  • Immune reconstitution inflammatory syndrome
  • Liver transplantation
  • Tacrolimus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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