Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia

Giovanni D'Arena; Maria Luigia Vigliotti; Vincenzo Pizza; Alfredo Tartarone; Giampiero Volpe; Giovanni Iodice; Nicola Di Renzo

doi:10.1080/10428190410001672149

Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia

Giovanni D'Arena, Maria Luigia Vigliotti, Vincenzo Pizza, Alfredo Tartarone, Giampiero Volpe, Giovanni Iodice, Nicola Di Renzo

IRCCS Centro di Riferimento Oncologico della Basilicata (CROB)

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.

Original language	English
Pages (from-to)	1489-1490
Number of pages	2
Journal	Leukemia and Lymphoma
Volume	45
Issue number	7
DOIs	https://doi.org/10.1080/10428190410001672149
Publication status	Published - Jul 2004

Keywords

B-cell chronic lymphocytic leukemia
Guillain-Barré syndrome
Mobilization therapy

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190410001672149

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Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia. / D'Arena, Giovanni; Vigliotti, Maria Luigia; Pizza, Vincenzo; Tartarone, Alfredo; Volpe, Giampiero; Iodice, Giovanni; Di Renzo, Nicola.

In: Leukemia and Lymphoma, Vol. 45, No. 7, 07.2004, p. 1489-1490.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report a case of Guillain-Barr{\'e} Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.",

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AU - Volpe, Giampiero

AU - Iodice, Giovanni

AU - Di Renzo, Nicola

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Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia

Abstract

Keywords

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