TY - JOUR
T1 - Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia
AU - D'Arena, Giovanni
AU - Vigliotti, Maria Luigia
AU - Pizza, Vincenzo
AU - Tartarone, Alfredo
AU - Volpe, Giampiero
AU - Iodice, Giovanni
AU - Di Renzo, Nicola
PY - 2004/7
Y1 - 2004/7
N2 - We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.
AB - We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.
KW - B-cell chronic lymphocytic leukemia
KW - Guillain-Barré syndrome
KW - Mobilization therapy
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U2 - 10.1080/10428190410001672149
DO - 10.1080/10428190410001672149
M3 - Article
C2 - 15359655
AN - SCOPUS:2542523738
VL - 45
SP - 1489
EP - 1490
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 7
ER -