Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia

Giovanni D'Arena, Maria Luigia Vigliotti, Vincenzo Pizza, Alfredo Tartarone, Giampiero Volpe, Giovanni Iodice, Nicola Di Renzo

Research output: Contribution to journalArticle

Abstract

We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.

Original languageEnglish
Pages (from-to)1489-1490
Number of pages2
JournalLeukemia and Lymphoma
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2004

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Keywords

  • B-cell chronic lymphocytic leukemia
  • Guillain-Barré syndrome
  • Mobilization therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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