Gut function and immune and inflammatory responses in patients perioperatively fed with supplemented enteral formulas

Marco Braga, Luca Gianotti, Andrea Cestari, Andrea Vignali, Fabio Pellegatta, Alberto Dolci, Valerio Di Carlo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate if the perioperative administration of a supplemented enteral formula modulates selective inflammatory and immune variables and gut function after surgery. Design: Prospective, randomized, double-blind, clinical trial. Setting: Department of surgery, university hospital. Patients: Forty patients with neoplasm of the colorectum or stomach. Intervention: Seven days before surgery, the patients drank 1 L/d of a control enteral formula (n=20) or the same formula enriched with arginine, RNA, and ω-3 fatty acids (n= 20). Jejunal infusion with the same formulas was started 6 hours after operation and continued until day 7. Main Outcome Measures: Immune response was determined by phagocytosis ability and respiratory burst of polymorphonuclear cells, and inflammatory response by plasma levels of C-reactive protein. Operative intestinal microperfusion, postoperative intestinal mucosa oxygen metabolism, and plasma intestinal isoenzyme of alkaline phosphatase were used as indicators of gut function. Plasma nitric oxide also was determined. Results: In the enriched group, phagocytosis ability and respiratory burst after surgery was higher (P

Original languageEnglish
Pages (from-to)1257-1265
Number of pages9
JournalArchives of Surgery
Volume131
Issue number12
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Surgery

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