Gut Mesenchymal Stromal Cells in Immunity

Valeria Messina, Carla Buccione, Giulia Marotta, Giovanna Ziccheddu, Michele Signore, Gianfranco Mattia, Rossella Puglisi, Benedetto Sacchetti, Livia Biancone, Mauro Valtieri

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Mesenchymal stromal cells (MSCs), first found in bone marrow (BM), are the structural architects of all organs, participating in most biological functions. MSCs possess tissue-specific signatures that allow their discrimination according to their origin and location. Among their multiple functions, MSCs closely interact with immune cells, orchestrating their activity to maintain overall homeostasis. The phenotype of tissue MSCs residing in the bowel overlaps with myofibroblasts, lining the bottom walls of intestinal crypts (pericryptal) or interspersed within intestinal submucosa (intercryptal). In Crohn's disease, intestinal MSCs are tightly stacked in a chronic inflammatory milieu, which causes their enforced expression of Class II major histocompatibility complex (MHC). The absence of Class II MHC is a hallmark for immune-modulator and tolerogenic properties of normal MSCs and, vice versa, the expression of HLA-DR is peculiar to antigen presenting cells, that is, immune-activator cells. Interferon gamma (IFNγ) is responsible for induction of Class II MHC expression on intestinal MSCs. The reversal of myofibroblasts/MSCs from an immune-modulator to an activator phenotype in Crohn's disease results in the formation of a fibrotic tube subverting the intestinal structure. Epithelial metaplastic areas in this context can progress to dysplasia and cancer.

Original languageEnglish
Article number8482326
JournalStem Cells International
Volume2017
DOIs
Publication statusPublished - Jan 1 2017

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Mesenchymal Stromal Cells
Immunity
Major Histocompatibility Complex
Myofibroblasts
Crohn Disease
Phenotype
HLA-DR Antigens
Antigen-Presenting Cells
Interferon-gamma
Homeostasis
Bone Marrow
Neoplasms

Keywords

  • Immunity

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Gut Mesenchymal Stromal Cells in Immunity. / Messina, Valeria; Buccione, Carla; Marotta, Giulia; Ziccheddu, Giovanna; Signore, Michele; Mattia, Gianfranco; Puglisi, Rossella; Sacchetti, Benedetto; Biancone, Livia; Valtieri, Mauro.

In: Stem Cells International, Vol. 2017, 8482326, 01.01.2017.

Research output: Contribution to journalReview article

Messina, V, Buccione, C, Marotta, G, Ziccheddu, G, Signore, M, Mattia, G, Puglisi, R, Sacchetti, B, Biancone, L & Valtieri, M 2017, 'Gut Mesenchymal Stromal Cells in Immunity', Stem Cells International, vol. 2017, 8482326. https://doi.org/10.1155/2017/8482326
Messina V, Buccione C, Marotta G, Ziccheddu G, Signore M, Mattia G et al. Gut Mesenchymal Stromal Cells in Immunity. Stem Cells International. 2017 Jan 1;2017. 8482326. https://doi.org/10.1155/2017/8482326
Messina, Valeria ; Buccione, Carla ; Marotta, Giulia ; Ziccheddu, Giovanna ; Signore, Michele ; Mattia, Gianfranco ; Puglisi, Rossella ; Sacchetti, Benedetto ; Biancone, Livia ; Valtieri, Mauro. / Gut Mesenchymal Stromal Cells in Immunity. In: Stem Cells International. 2017 ; Vol. 2017.
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