Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy

Stefania Gori; Alessandro Inno; Lorenzo Belluomini; Paolo Bocus; Zeno Bisoffi; Antonio Russo; Guido Arcaro

doi:10.1016/j.critrevonc.2019.09.003

Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy

Stefania Gori, Alessandro Inno, Lorenzo Belluomini, Paolo Bocus, Zeno Bisoffi, Antonio Russo, Guido Arcaro

Istituto Sacro Cuore Don Calabria - Negrar

Research output: Contribution to journal › Review article › peer-review

Abstract

Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.

Original language	English
Pages (from-to)	139-147
Number of pages	9
Journal	Critical Reviews in Oncology/Hematology
Volume	143
DOIs	https://doi.org/10.1016/j.critrevonc.2019.09.003
Publication status	Published - Nov 2019

Keywords

5-Fluorouracil
Cisplatin
Cyclophosphamide
Gemcitabine
Immune checkpoint inhibitors
Irinotecan
Microbiota
Tyrosine kinase inhibitors

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.critrevonc.2019.09.003

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Gut microbiota and cancer : How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy. / Gori, Stefania; Inno, Alessandro; Belluomini, Lorenzo; Bocus, Paolo; Bisoffi, Zeno; Russo, Antonio; Arcaro, Guido.

In: Critical Reviews in Oncology/Hematology, Vol. 143, 11.2019, p. 139-147.

Research output: Contribution to journal › Review article › peer-review

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title = "Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy",

abstract = "Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.",

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AU - Gori, Stefania

AU - Inno, Alessandro

AU - Belluomini, Lorenzo

AU - Bocus, Paolo

AU - Bisoffi, Zeno

AU - Russo, Antonio

AU - Arcaro, Guido

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AB - Gut microbiota is involved in gastrointestinal carcinogenesis. Also, it modulates the activity, efficacy and toxicity of several chemotherapy agents, such as gemcitabine, cyclophosphamide, irinotecan, cisplatin and 5-Fluorouracil, and target therapy, such as tyrosine kinase inhibitors. More recently, accumulating data suggest that the composition of gut microbiota may also affect efficacy and toxicity of cancer immunotherapy. Therefore, the manipulation of gut microbiota through antibiotics, probiotics, prebiotics or fecal transplantation has been investigating with the aim to improve efficacy and mitigate toxicity of anticancer drugs.

KW - 5-Fluorouracil

KW - Cisplatin

KW - Cyclophosphamide

KW - Gemcitabine

KW - Immune checkpoint inhibitors

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KW - Microbiota

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Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy

Abstract

Keywords

ASJC Scopus subject areas

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