Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

Emmanuel Biver, Francis Berenbaum, Ana M. Valdes, Islene Araujo de Carvalho, Laure B. Bindels, Maria Luisa Brandi, Philip C. Calder, Vincenzo Castronovo, Etienne Cavalier, Antonio Cherubini, Cyrus Cooper, Elaine Dennison, Claudio Franceschi, Nicholas Fuggle, Andrea Laslop, Pierre Miossec, Thierry Thomas, Sansin Tuzun, Nicola Veronese, Mila VlaskovskaJean Yves Reginster, René Rizzoli

Research output: Contribution to journalReview article

Abstract

The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis.

Original languageEnglish
Article number100946
JournalAgeing Research Reviews
Volume55
DOIs
Publication statusPublished - Nov 1 2019

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Musculoskeletal Diseases
Nutrition
Metabolites
Metabolism
Sugars
Osteoarthritis
Osteoporosis
Consensus
Animals
Fats
Economics
Fibers
Chemical analysis
Pharmaceutical Preparations
Dysbiosis
Biological Availability
Gastrointestinal Microbiome
Life Expectancy
Life Style
Animal Models

Keywords

  • Dysbiosis
  • Gut microbiota
  • Inflammaging
  • Modern diet
  • Obesity
  • Osteoarthritis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

Cite this

Gut microbiota and osteoarthritis management : An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO). / Biver, Emmanuel; Berenbaum, Francis; Valdes, Ana M.; Araujo de Carvalho, Islene; Bindels, Laure B.; Brandi, Maria Luisa; Calder, Philip C.; Castronovo, Vincenzo; Cavalier, Etienne; Cherubini, Antonio; Cooper, Cyrus; Dennison, Elaine; Franceschi, Claudio; Fuggle, Nicholas; Laslop, Andrea; Miossec, Pierre; Thomas, Thierry; Tuzun, Sansin; Veronese, Nicola; Vlaskovska, Mila; Reginster, Jean Yves; Rizzoli, René.

In: Ageing Research Reviews, Vol. 55, 100946, 01.11.2019.

Research output: Contribution to journalReview article

Biver, E, Berenbaum, F, Valdes, AM, Araujo de Carvalho, I, Bindels, LB, Brandi, ML, Calder, PC, Castronovo, V, Cavalier, E, Cherubini, A, Cooper, C, Dennison, E, Franceschi, C, Fuggle, N, Laslop, A, Miossec, P, Thomas, T, Tuzun, S, Veronese, N, Vlaskovska, M, Reginster, JY & Rizzoli, R 2019, 'Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)', Ageing Research Reviews, vol. 55, 100946. https://doi.org/10.1016/j.arr.2019.100946
Biver, Emmanuel ; Berenbaum, Francis ; Valdes, Ana M. ; Araujo de Carvalho, Islene ; Bindels, Laure B. ; Brandi, Maria Luisa ; Calder, Philip C. ; Castronovo, Vincenzo ; Cavalier, Etienne ; Cherubini, Antonio ; Cooper, Cyrus ; Dennison, Elaine ; Franceschi, Claudio ; Fuggle, Nicholas ; Laslop, Andrea ; Miossec, Pierre ; Thomas, Thierry ; Tuzun, Sansin ; Veronese, Nicola ; Vlaskovska, Mila ; Reginster, Jean Yves ; Rizzoli, René. / Gut microbiota and osteoarthritis management : An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO). In: Ageing Research Reviews. 2019 ; Vol. 55.
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