Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease

Stefano Bibbò, Gianluca Ianiro, Maria Pina Dore, Claudia Simonelli, Estelle E. Newton, Giovanni Cammarota

Research output: Contribution to journalReview articlepeer-review

Abstract

The prevalence of nonalcoholic fatty liver disease and the consequent burden of metabolic syndrome have increased in recent years. Although the pathogenesis of nonalcoholic fatty liver disease is not completely understood, it is thought to be the hepatic manifestation of the dysregulation of insulin-dependent pathways leading to insulin resistance and adipose tissue accumulation in the liver. Recently, the gut-liver axis has been proposed as a key player in the pathogenesis of NAFLD, as the passage of bacteria-derived products into the portal circulation could lead to a trigger of innate immunity, which in turn leads to liver inflammation. Additionally, higher prevalence of intestinal dysbiosis, larger production of endogenous ethanol, and higher prevalence of increased intestinal permeability and bacterial translocation were found in patients with liver injury. In this review, we describe the role of intestinal dysbiosis in the activation of the inflammatory cascade in NAFLD.

Original languageEnglish
Article number9321643
JournalMediators of Inflammation
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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