Abstract
The emergence of antimicrobial resistance (AMR) is of great concern to global public health. Treatment of multi-drug resistant (MDR) infections is a major clinical challenge: the increase in antibiotic resistance leads to a greater risk of therapeutic failure, relapses, longer hospitalizations, and worse clinical outcomes. Currently, there are no validated treatments for many MDR or pandrug-resistant (PDR) infections, and preventing the spread of these pathogens through hospital infection control procedures and antimicrobial stewardship programs is often the only tool available to healthcare providers. Therefore, new solutions to control the colonization of MDR pathogens are urgently needed. In this narrative review, we discuss current knowledge of microbiota-mediated mechanisms of AMR and strategies for MDR colonization control. We focus particularly on fecal microbiota transplantation for MDR intestinal decolonization and report updated literature on its current clinical use.
| Original language | English |
|---|---|
| Pages (from-to) | 1704 |
| Journal | Frontiers in Microbiology |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 2019 |
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Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization : Present and Future Perspectives. / Gargiullo, Livia; Del Chierico, Federica; D'Argenio, Patrizia; Putignani, Lorenza.
In: Frontiers in Microbiology, Vol. 10, 2019, p. 1704.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization
T2 - Present and Future Perspectives
AU - Gargiullo, Livia
AU - Del Chierico, Federica
AU - D'Argenio, Patrizia
AU - Putignani, Lorenza
PY - 2019
Y1 - 2019
N2 - The emergence of antimicrobial resistance (AMR) is of great concern to global public health. Treatment of multi-drug resistant (MDR) infections is a major clinical challenge: the increase in antibiotic resistance leads to a greater risk of therapeutic failure, relapses, longer hospitalizations, and worse clinical outcomes. Currently, there are no validated treatments for many MDR or pandrug-resistant (PDR) infections, and preventing the spread of these pathogens through hospital infection control procedures and antimicrobial stewardship programs is often the only tool available to healthcare providers. Therefore, new solutions to control the colonization of MDR pathogens are urgently needed. In this narrative review, we discuss current knowledge of microbiota-mediated mechanisms of AMR and strategies for MDR colonization control. We focus particularly on fecal microbiota transplantation for MDR intestinal decolonization and report updated literature on its current clinical use.
AB - The emergence of antimicrobial resistance (AMR) is of great concern to global public health. Treatment of multi-drug resistant (MDR) infections is a major clinical challenge: the increase in antibiotic resistance leads to a greater risk of therapeutic failure, relapses, longer hospitalizations, and worse clinical outcomes. Currently, there are no validated treatments for many MDR or pandrug-resistant (PDR) infections, and preventing the spread of these pathogens through hospital infection control procedures and antimicrobial stewardship programs is often the only tool available to healthcare providers. Therefore, new solutions to control the colonization of MDR pathogens are urgently needed. In this narrative review, we discuss current knowledge of microbiota-mediated mechanisms of AMR and strategies for MDR colonization control. We focus particularly on fecal microbiota transplantation for MDR intestinal decolonization and report updated literature on its current clinical use.
U2 - 10.3389/fmicb.2019.01704
DO - 10.3389/fmicb.2019.01704
M3 - Review article
C2 - 31402904
VL - 10
SP - 1704
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
SN - 1664-302X
ER -