Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study

Andrea Fontana, Concetta Panebianco, Andrea Picchianti-Diamanti, Bruno Laganà, Duccio Cavalieri, Adele Potenza, Riccardo Pracella, Elena Binda, Massimiliano Copetti, Valerio Pazienza

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND AIMS: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. MATERIALS AND METHODS: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). RESULTS: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32-41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. CONCLUSIONS: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.

Original languageEnglish
JournalInternational Journal of Environmental Research and Public Health
Volume16
Issue number21
DOIs
Publication statusPublished - Oct 23 2019

Fingerprint

Microbiota
Healthy Volunteers
Feeding Behavior
rRNA Genes
Life Style
Gastrointestinal Microbiome
Population

Keywords

  • dysbiosis
  • eubiosis
  • geographical location
  • microbiota

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin : An Italian Pilot Study. / Fontana, Andrea; Panebianco, Concetta; Picchianti-Diamanti, Andrea; Laganà, Bruno; Cavalieri, Duccio; Potenza, Adele; Pracella, Riccardo; Binda, Elena; Copetti, Massimiliano; Pazienza, Valerio.

In: International Journal of Environmental Research and Public Health, Vol. 16, No. 21, 23.10.2019.

Research output: Contribution to journalArticle

@article{0657bbb3e3a6400c9b464e726578525c,
title = "Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study",
abstract = "BACKGROUND AND AIMS: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. MATERIALS AND METHODS: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). RESULTS: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32-41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. CONCLUSIONS: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.",
keywords = "dysbiosis, eubiosis, geographical location, microbiota",
author = "Andrea Fontana and Concetta Panebianco and Andrea Picchianti-Diamanti and Bruno Lagan{\`a} and Duccio Cavalieri and Adele Potenza and Riccardo Pracella and Elena Binda and Massimiliano Copetti and Valerio Pazienza",
year = "2019",
month = "10",
day = "23",
doi = "10.3390/ijerph16214065",
language = "English",
volume = "16",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "MDPI AG",
number = "21",

}

TY - JOUR

T1 - Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin

T2 - An Italian Pilot Study

AU - Fontana, Andrea

AU - Panebianco, Concetta

AU - Picchianti-Diamanti, Andrea

AU - Laganà, Bruno

AU - Cavalieri, Duccio

AU - Potenza, Adele

AU - Pracella, Riccardo

AU - Binda, Elena

AU - Copetti, Massimiliano

AU - Pazienza, Valerio

PY - 2019/10/23

Y1 - 2019/10/23

N2 - BACKGROUND AND AIMS: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. MATERIALS AND METHODS: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). RESULTS: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32-41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. CONCLUSIONS: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.

AB - BACKGROUND AND AIMS: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. MATERIALS AND METHODS: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). RESULTS: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32-41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. CONCLUSIONS: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.

KW - dysbiosis

KW - eubiosis

KW - geographical location

KW - microbiota

UR - http://www.scopus.com/inward/record.url?scp=85074172918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074172918&partnerID=8YFLogxK

U2 - 10.3390/ijerph16214065

DO - 10.3390/ijerph16214065

M3 - Article

C2 - 31652705

AN - SCOPUS:85074172918

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 21

ER -