Gynaecological and obstetrical problems in women with different bleeding disorders

S. M. Siboni, M. Spreafico, L. Calò, A. Maino, E. Santagostino, A. B. Federici, F. Peyvandi

Research output: Contribution to journalArticlepeer-review


The aim of this case-control study was to analyse the prevalence of gynaecological, obstetrical and other more general bleeding symptoms in 114 women affected by various inherited bleeding disorders, who were compared with 114 apparently healthy women. Retrospective information were collected by means of two specific questionnaires, one on gynaecological and obstetrical bleeding symptoms, with special focus on the presence of menorrhagia as defined by a pictorial blood loss assessment chart (PBAC); and the other on general bleeding symptoms, whose severity was graded by means of the bleeding score (BS). Compared to normal women, the whole group of women with inherited bleeding disorders had a higher prevalence of excessive bleeding at menarche (25% vs. 5%, P <0.0001) and menorrhagia (59% vs. 46%, P = 0.06). Affected women also had a higher frequency than controls of general bleeding symptoms that scored as severe by a BS ≥ 12 (49% vs. 0%, P <0.0001). In affected women, the BS increased according to the severity of the haemostasis defect. In conclusions, the BS and the PBAC are simple tools to evaluate the severity of general bleeding symptoms and menorrhagia in women with inherited bleeding disorders. These instruments may help to identify those women for whom a therapeutic intervention is warranted.

Original languageEnglish
Pages (from-to)1291-1299
Number of pages9
Issue number6
Publication statusPublished - Nov 2009


  • Haemophilia
  • Menorrhagia
  • Pregnancy
  • Rare bleeding disorders
  • Von Willebrand disease

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)


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