Gynecomastia and breast pain induced by adjuvant therapy with bicalutamide after radical prostatectomy in patients with prostate cancer: The role of tamoxifen and radiotherapy

Giuseppe Di Lorenzo, Sisto Perdoná, Sabino De Placido, Massimo D'Armiento, Antonio Gallo, Rocco Damiano, Domenico Pingitore, Luigi Gallo, Marco De Sio, Riccardo Autorino

Research output: Contribution to journalArticle

Abstract

Purpose: We investigated the role of tamoxifen. and radiotherapy (RT) for the prevention and treatment of gynecomastia and breast pain during adjuvant bicalutamide monotherapy after radical prostatectomy (RP) in patients with prostate cancer. Also, we evaluated their effects on patient hormonal status, quality of life (QOL), sexual function and prostate specific antigen relapse-free survival. Materials and Methods: This was a multicenter prospective trial. From January 2002 to February 2004, 102 patients who had undergone RP for localized or locally advanced prostate cancer were recruited and randomized into 3 groups, namely group 1-those receiving only 150 mg bicalutamide as adjuvant hormonal therapy, group 2-those receiving bicalutamide and 10 mg tamoxifen, and group 3-those receiving bicalutamide and RT. Patients in group 1 in whom gynecomastia or breast pain developed were subsequently randomized to receive tamoxifen or RT soon after symptoms started. Gynecomastia, breast pain, prostate specific antigen, QOL, sexual function and hormonal levels were assessed. Minimum followup was 12 months. Results: Of group 1 patients 67% had gynecomastia compared with 8% in group 2 and 34% in group 3. Breast pain was more frequent in group 1 than in groups 2 and 3 (58% vs 7% and 30%, respectively). Differences were significant between groups 1 and 2 (OR 0.12 p

Original languageEnglish
Pages (from-to)2197-2203
Number of pages7
JournalJournal of Urology
Volume174
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Gynecomastia
  • Pain
  • Prostate
  • Prostatectomy
  • Quality of life

ASJC Scopus subject areas

  • Urology

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