Abstract
The objective of our study was to determine whether and how frequently MHC class I gene alterations occur in fibrosarcomas induced in BALB/c mice by the carcinogen 3-methylcholanthrene (3-MCA). Southern blot was performed to analyze the genomic organization of class I genes in a panel of twenty tumors of different immunogenic strenght used at early in vivo passages. Our results rule out the presence of gross rearrangements or deletions in the H-2 class I genes of the tumors tested and indicate that the frequency of detectable class I alterations giving rise to restriction fragments length polymorphism (RFLP) should be very low.
Original language | English |
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Pages (from-to) | 129-135 |
Number of pages | 7 |
Journal | Experimental and Clinical Immunogenetics |
Volume | 7 |
Issue number | 2 |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Immunology
- Genetics(clinical)
- Genetics