H and L ferritins in myocardium in iron overload

Eloisa Arbustini, Maurizia Grasso, Guido Rindi, Paolo Arosio, Antonello Gavazzi, Marta Diegoli, Manuela Bramerio, Sonia Levi, Giovanni Barosi

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Ferritin is an iron-containing protein composed of 2 subunits (H and L) with largely different primary structures and immunochemical properties. 1 The normal L-subunit-rich, basic isoferritin is prevalent in the liver and spleen, whereas the H-subunit-rich, acidic isoferritin predominates in the heart, pancreas and kidneys.2 A variation in heart isoferritin was reported in iron-overloaded patients,2 and the absence of the more acidic isoferritin was hypothesized to be specific for hereditary hemochromatosis.3 These observations prompted us to perform immunohistochemical investigations on H and L ferritins in endomyocardial biopsy samples of patients with primary or secondary iron overload, using monoclonal antibodies to H and L. This study attempted to assess the pattern of heart isoferritins and the factors influencing their occurrence in iron accumulation.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalThe American Journal of Cardiology
Issue number11
Publication statusPublished - Nov 1 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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