TY - JOUR
T1 - H. pylori infection and gastric cancer
T2 - State of the art (Review)
AU - Conteduca, Vincenza
AU - Sansonno, Domenico
AU - Lauletta, Gianfranco
AU - Russi, Sabino
AU - Ingravallo, Giuseppe
AU - Dammacco, Franco
PY - 2013/1
Y1 - 2013/1
N2 - Gastric cancer (GC) is one of the leading types of cancer worldwide, particularly in East Asian populations. Helicobacter pylori (HP) infection has been established as a major risk factor for GC. Although more than 50% of the world population is infected with this bacterium, less than 2% develop GC. Therefore, further risk factors (such as host genetic polymorphisms and lifestyle, as well as environmental and epigenetic factors) may also play a role in its occurrence. The correlation between HP infection and GC represents a typical model of a multi-step process, characterized by some pre-neoplastic lesions with a high risk of progression (atrophic gastritis, intestinal metaplasia and dysplasia). In addition, HP also plays an oncogenic role in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, that accounts for approximately 3% of all gastric tumors. Hyperplastic polyps often arise in patients with atrophic gastric mucosa and HP-associated gastritis (25% of cases); however, their malignant trasformation is rare (
AB - Gastric cancer (GC) is one of the leading types of cancer worldwide, particularly in East Asian populations. Helicobacter pylori (HP) infection has been established as a major risk factor for GC. Although more than 50% of the world population is infected with this bacterium, less than 2% develop GC. Therefore, further risk factors (such as host genetic polymorphisms and lifestyle, as well as environmental and epigenetic factors) may also play a role in its occurrence. The correlation between HP infection and GC represents a typical model of a multi-step process, characterized by some pre-neoplastic lesions with a high risk of progression (atrophic gastritis, intestinal metaplasia and dysplasia). In addition, HP also plays an oncogenic role in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, that accounts for approximately 3% of all gastric tumors. Hyperplastic polyps often arise in patients with atrophic gastric mucosa and HP-associated gastritis (25% of cases); however, their malignant trasformation is rare (
KW - Endoscopic surveillance
KW - Gastric cancer
KW - Gastric polyps
KW - Helicobacter pylori
KW - Helicobacter pylori eradication
KW - Mucosa-associated lymphoid tissue lymphoma
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U2 - 10.3892/ijo.2012.1701
DO - 10.3892/ijo.2012.1701
M3 - Article
C2 - 23165522
AN - SCOPUS:84873687878
VL - 42
SP - 5
EP - 18
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 1
ER -