H. pylori infection and gastric cancer: State of the art (Review)

Vincenza Conteduca, Domenico Sansonno, Gianfranco Lauletta, Sabino Russi, Giuseppe Ingravallo, Franco Dammacco

Research output: Contribution to journalArticle

Abstract

Gastric cancer (GC) is one of the leading types of cancer worldwide, particularly in East Asian populations. Helicobacter pylori (HP) infection has been established as a major risk factor for GC. Although more than 50% of the world population is infected with this bacterium, less than 2% develop GC. Therefore, further risk factors (such as host genetic polymorphisms and lifestyle, as well as environmental and epigenetic factors) may also play a role in its occurrence. The correlation between HP infection and GC represents a typical model of a multi-step process, characterized by some pre-neoplastic lesions with a high risk of progression (atrophic gastritis, intestinal metaplasia and dysplasia). In addition, HP also plays an oncogenic role in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, that accounts for approximately 3% of all gastric tumors. Hyperplastic polyps often arise in patients with atrophic gastric mucosa and HP-associated gastritis (25% of cases); however, their malignant trasformation is rare (

Original languageEnglish
Pages (from-to)5-18
Number of pages14
JournalInternational Journal of Oncology
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Keywords

  • Endoscopic surveillance
  • Gastric cancer
  • Gastric polyps
  • Helicobacter pylori
  • Helicobacter pylori eradication
  • Mucosa-associated lymphoid tissue lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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