Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma

L. Ceccherini-Nelli, V. de Re, A. Viel, G. Molaro, L. Zilli, C. Clemente, M. Boiocchi

Research output: Contribution to journalArticlepeer-review

Abstract

It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBritish Journal of Cancer
Volume56
Issue number1
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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