HAART simplification with lopinavir/ritonavir monotherapy in HIV/HCV co-infected patients starting anti-HCV treatment: A randomised pilot study (KaMon study)

Hamid Hasson, Laura Galli, Giulia Gallotta, Valentina Neri, Pierluigi Blanc, Marco D'annunzio, Giulia Morsica, Salvatore Sollima, Marco Merli, Adriano Lazzarin, Caterina Uberti-Foppa

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Abstract

The aim of this randomised, prospective, open-label, multicentre pilot clinical trial was to compare the 48-week tox-icity profile of lopinavir/ritonavir (LPV/r) monotherapy with LPV/r-based HAART (KaMon = Kaletra monotherapy) in HIV/HCV patients undergoing HCV treatment. The study involved 30 HIV/HCV co-infected patients naïve to anti-HCV therapy. One patient in each arm (6.7%) discontinued anti-HCV therapy because of adverse events. There were no significant between-group differences in terms of the proportion of patients experiencing AEs (p=0.999) or the number of grade 3-4 AEs (p=0.146). No HIV failure was observed. The safety profile of LPV/r monotherapy was similar to that of LPV/r-based HAART, thus encouraging HAART simplification in patients receiving anti-HCV treatment.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalNew Microbiologica
Volume35
Issue number4
Publication statusPublished - 2012

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Keywords

  • Anti-HCV drugs
  • HAART-simplification strategy
  • LPV/r monotherapy
  • Tolerability of HIV/HCV treatments

ASJC Scopus subject areas

  • Microbiology (medical)

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