Habituation to pain in "medication overuse headache": A CO 2 laser-evoked potential study

Diana Ferraro, Catello Vollono, Roberto Miliucci, Daniela Virdis, Liala De Armas, Costanza Pazzaglia, Domenica Le Pera, Samuela Tarantino, Martina Balestri, Girolamo Di Trapani, Massimiliano Valeriani

Research output: Contribution to journalArticlepeer-review


Objective.- Our aim was to investigate CO2 laser-evoked potential (LEP) habituation to experimental pain in a group of patients affected by medication-overuse headache, with a history of episodic migraine becoming chronic, before and after treatment, consisting in acute medication withdrawal and a preventive treatment cycle. Background.- One of the main features of LEPs in migraineurs is a lower habituation to repetitive noxious stimuli during the interictal phase. Methods.- LEPs were recorded to stimulation of both the right hand and the right perioral region in 14 patients and in 14 healthy subjects. The habituation of both the N1 and the vertex N2/P2 components was assessed by measuring the LEP amplitude changes across 3 consecutive repetitions of 30 trials each. Results.- In the 8 patients who had clinically improved after treatment, the N2/P2 amplitude habituation was significantly higher after treatment than before treatment following both hand (F = 43.2, P

Original languageEnglish
Pages (from-to)792-807
Number of pages16
Issue number5
Publication statusPublished - May 2012


  • habituation
  • laser-evoked potential
  • medication-overuse headache
  • migraine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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