Haemodiafiltration use in children

data from the Italian Pediatric Dialysis Registry

Fabio Paglialonga, Enrico Vidal, Carmine Pecoraro, Isabella Guzzo, Mario Giordano, Bruno Gianoglio, Ciro Corrado, Rosa Roperto, Ilse Ratsch, Salvatore Luzio, Luisa Murer, Silvia Consolo, Giovanni Pieri, Giovanni Montini, Alberto Edefonti, Enrico Verrina

Research output: Contribution to journalArticle

Abstract

BACKGROUND: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy.

METHODS: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry's database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors.

RESULTS: One hundred forty-one out of 198 patients were treated exclusively with bicarbonate HD (71.2%), 57 with HDF (28.8%). Patients treated with HDF were younger (median 9.7 vs 13.2 years, p = 0.0008), were less often incident patients (52.6% vs 75.9%, p = 0.0031), had longer duration of the HD cycle (26.9 vs 20.8 months, p = 0.0036) and had a longer time to renal transplantation (32 vs 25 months, p = 0.0029) than those treated with bicarbonate HD only. The percentage of patients treated with HDF increased with dialysis vintage (16.9% at 6 months, 38.1% after more than 2 years of dialysis). The use of HDF was stable over time and was more common in the largest centres.

CONCLUSIONS: Over the observation period, HDF use in Italy has been limited to roughly a quarter of patients on extracorporeal dialysis, in particular to those with high dialysis vintage, younger age or a long expected waiting time to renal transplantation.

Original languageEnglish
JournalPediatric Nephrology
DOIs
Publication statusE-pub ahead of print - Jan 5 2019

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Hemodiafiltration
Registries
Dialysis
Renal Dialysis
Pediatrics
Bicarbonates
Kidney Transplantation
Italy
Observation
Databases
Survival

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Haemodiafiltration use in children : data from the Italian Pediatric Dialysis Registry. / Paglialonga, Fabio; Vidal, Enrico; Pecoraro, Carmine; Guzzo, Isabella; Giordano, Mario; Gianoglio, Bruno; Corrado, Ciro; Roperto, Rosa; Ratsch, Ilse; Luzio, Salvatore; Murer, Luisa; Consolo, Silvia; Pieri, Giovanni; Montini, Giovanni; Edefonti, Alberto; Verrina, Enrico.

In: Pediatric Nephrology, 05.01.2019.

Research output: Contribution to journalArticle

Paglialonga, F, Vidal, E, Pecoraro, C, Guzzo, I, Giordano, M, Gianoglio, B, Corrado, C, Roperto, R, Ratsch, I, Luzio, S, Murer, L, Consolo, S, Pieri, G, Montini, G, Edefonti, A & Verrina, E 2019, 'Haemodiafiltration use in children: data from the Italian Pediatric Dialysis Registry', Pediatric Nephrology. https://doi.org/10.1007/s00467-018-4184-z
Paglialonga, Fabio ; Vidal, Enrico ; Pecoraro, Carmine ; Guzzo, Isabella ; Giordano, Mario ; Gianoglio, Bruno ; Corrado, Ciro ; Roperto, Rosa ; Ratsch, Ilse ; Luzio, Salvatore ; Murer, Luisa ; Consolo, Silvia ; Pieri, Giovanni ; Montini, Giovanni ; Edefonti, Alberto ; Verrina, Enrico. / Haemodiafiltration use in children : data from the Italian Pediatric Dialysis Registry. In: Pediatric Nephrology. 2019.
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abstract = "BACKGROUND: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy.METHODS: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry's database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors.RESULTS: One hundred forty-one out of 198 patients were treated exclusively with bicarbonate HD (71.2{\%}), 57 with HDF (28.8{\%}). Patients treated with HDF were younger (median 9.7 vs 13.2 years, p = 0.0008), were less often incident patients (52.6{\%} vs 75.9{\%}, p = 0.0031), had longer duration of the HD cycle (26.9 vs 20.8 months, p = 0.0036) and had a longer time to renal transplantation (32 vs 25 months, p = 0.0029) than those treated with bicarbonate HD only. The percentage of patients treated with HDF increased with dialysis vintage (16.9{\%} at 6 months, 38.1{\%} after more than 2 years of dialysis). The use of HDF was stable over time and was more common in the largest centres.CONCLUSIONS: Over the observation period, HDF use in Italy has been limited to roughly a quarter of patients on extracorporeal dialysis, in particular to those with high dialysis vintage, younger age or a long expected waiting time to renal transplantation.",
author = "Fabio Paglialonga and Enrico Vidal and Carmine Pecoraro and Isabella Guzzo and Mario Giordano and Bruno Gianoglio and Ciro Corrado and Rosa Roperto and Ilse Ratsch and Salvatore Luzio and Luisa Murer and Silvia Consolo and Giovanni Pieri and Giovanni Montini and Alberto Edefonti and Enrico Verrina",
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TY - JOUR

T1 - Haemodiafiltration use in children

T2 - data from the Italian Pediatric Dialysis Registry

AU - Paglialonga, Fabio

AU - Vidal, Enrico

AU - Pecoraro, Carmine

AU - Guzzo, Isabella

AU - Giordano, Mario

AU - Gianoglio, Bruno

AU - Corrado, Ciro

AU - Roperto, Rosa

AU - Ratsch, Ilse

AU - Luzio, Salvatore

AU - Murer, Luisa

AU - Consolo, Silvia

AU - Pieri, Giovanni

AU - Montini, Giovanni

AU - Edefonti, Alberto

AU - Verrina, Enrico

PY - 2019/1/5

Y1 - 2019/1/5

N2 - BACKGROUND: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy.METHODS: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry's database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors.RESULTS: One hundred forty-one out of 198 patients were treated exclusively with bicarbonate HD (71.2%), 57 with HDF (28.8%). Patients treated with HDF were younger (median 9.7 vs 13.2 years, p = 0.0008), were less often incident patients (52.6% vs 75.9%, p = 0.0031), had longer duration of the HD cycle (26.9 vs 20.8 months, p = 0.0036) and had a longer time to renal transplantation (32 vs 25 months, p = 0.0029) than those treated with bicarbonate HD only. The percentage of patients treated with HDF increased with dialysis vintage (16.9% at 6 months, 38.1% after more than 2 years of dialysis). The use of HDF was stable over time and was more common in the largest centres.CONCLUSIONS: Over the observation period, HDF use in Italy has been limited to roughly a quarter of patients on extracorporeal dialysis, in particular to those with high dialysis vintage, younger age or a long expected waiting time to renal transplantation.

AB - BACKGROUND: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy.METHODS: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry's database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors.RESULTS: One hundred forty-one out of 198 patients were treated exclusively with bicarbonate HD (71.2%), 57 with HDF (28.8%). Patients treated with HDF were younger (median 9.7 vs 13.2 years, p = 0.0008), were less often incident patients (52.6% vs 75.9%, p = 0.0031), had longer duration of the HD cycle (26.9 vs 20.8 months, p = 0.0036) and had a longer time to renal transplantation (32 vs 25 months, p = 0.0029) than those treated with bicarbonate HD only. The percentage of patients treated with HDF increased with dialysis vintage (16.9% at 6 months, 38.1% after more than 2 years of dialysis). The use of HDF was stable over time and was more common in the largest centres.CONCLUSIONS: Over the observation period, HDF use in Italy has been limited to roughly a quarter of patients on extracorporeal dialysis, in particular to those with high dialysis vintage, younger age or a long expected waiting time to renal transplantation.

U2 - 10.1007/s00467-018-4184-z

DO - 10.1007/s00467-018-4184-z

M3 - Article

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

ER -