Haemodiafiltration use in children: data from the Italian Pediatric Dialysis Registry

Fabio Paglialonga, Enrico Vidal, Carmine Pecoraro, Isabella Guzzo, Mario Giordano, Bruno Gianoglio, Ciro Corrado, Rosa Roperto, Ilse Ratsch, Salvatore Luzio, Luisa Murer, Silvia Consolo, Giovanni Pieri, Giovanni Montini, Alberto Edefonti, Enrico Verrina

Research output: Contribution to journalReview articlepeer-review


Background: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy. Methods: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry’s database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors. Results: One hundred forty-one out of 198 patients were treated exclusively with bicarbonate HD (71.2%), 57 with HDF (28.8%). Patients treated with HDF were younger (median 9.7 vs 13.2 years, p = 0.0008), were less often incident patients (52.6% vs 75.9%, p = 0.0031), had longer duration of the HD cycle (26.9 vs 20.8 months, p = 0.0036) and had a longer time to renal transplantation (32 vs 25 months, p = 0.0029) than those treated with bicarbonate HD only. The percentage of patients treated with HDF increased with dialysis vintage (16.9% at 6 months, 38.1% after more than 2 years of dialysis). The use of HDF was stable over time and was more common in the largest centres. Conclusions: Over the observation period, HDF use in Italy has been limited to roughly a quarter of patients on extracorporeal dialysis, in particular to those with high dialysis vintage, younger age or a long expected waiting time to renal transplantation.

Original languageEnglish
Pages (from-to)1057-1063
Number of pages7
JournalPediatric Nephrology
Issue number6
Publication statusPublished - Jun 1 2019


  • Children
  • Extracorporeal dialysis
  • Haemodiafiltration
  • Haemodialysis
  • Paediatric dialysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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