Haemodialysis efficiency after long-term treatment with recombinant human erythropoietin

S. Casati, M. Campise, M. Crepaldi, J. Lobo, G. Graziani, C. Ponticelli

Research output: Contribution to journalArticle

Abstract

In 11 chronic haemodialysis patients we investigated whether the increase in haematocrit during recombinant human erythropoietin (rHuEPO) treatment might alter the long-term efficiency of haemodialysis. After correction of anaemia with rHuEPO (mean Ht 35±2% vs 19±2% at baseline) (p.001), mean predialysis creatinine and urea did not change, while predialysis phosphate (1.77±0.38 vs 1.51±0.29 mmol/l) were significantly increased (p 0.01). In six of the 11 rHuEPO treated patients a post- versus pre-dialysis haemoconcentration (haematocrit 44% vs 35%) not attributable to different ultrafiltration regimes, was observed. In these 6 patients mean predialysis phosphate, creatinine and urea tended to be higher, but not significantly, in comparison to the remaining 5 patients who did not haemoconcentrate. Dialyser clearances and total extractions for urea, creatinine, phosphate and inulin were compared to those of 11 matched haemodialysis patients with anaemia. No differences were observed either for small and middle molecule clearances or their extractions between rHuEPO and anaemic patients. In conclusion, dialysis efficiency is not affected if haematocrit values are kept about 35%.

Original languageEnglish
Pages (from-to)718-720
Number of pages3
JournalNephrology Dialysis Transplantation
Volume4
Issue number8
Publication statusPublished - 1989

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Erythropoietin
Renal Dialysis
Hematocrit
Urea
Creatinine
Phosphates
Anemia
Dialysis
Therapeutics
Inulin
Ultrafiltration

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Casati, S., Campise, M., Crepaldi, M., Lobo, J., Graziani, G., & Ponticelli, C. (1989). Haemodialysis efficiency after long-term treatment with recombinant human erythropoietin. Nephrology Dialysis Transplantation, 4(8), 718-720.

Haemodialysis efficiency after long-term treatment with recombinant human erythropoietin. / Casati, S.; Campise, M.; Crepaldi, M.; Lobo, J.; Graziani, G.; Ponticelli, C.

In: Nephrology Dialysis Transplantation, Vol. 4, No. 8, 1989, p. 718-720.

Research output: Contribution to journalArticle

Casati, S, Campise, M, Crepaldi, M, Lobo, J, Graziani, G & Ponticelli, C 1989, 'Haemodialysis efficiency after long-term treatment with recombinant human erythropoietin', Nephrology Dialysis Transplantation, vol. 4, no. 8, pp. 718-720.
Casati, S. ; Campise, M. ; Crepaldi, M. ; Lobo, J. ; Graziani, G. ; Ponticelli, C. / Haemodialysis efficiency after long-term treatment with recombinant human erythropoietin. In: Nephrology Dialysis Transplantation. 1989 ; Vol. 4, No. 8. pp. 718-720.
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