Haemodynamic and clinical effects of long-term treatment of essential hypertension with captopril

B. Ricciardelli, M. Volpe, B. Trimarco, N. De Luca, A. Cuocolo, L. Sacca', M. Condorelli

Research output: Contribution to journalArticlepeer-review

Abstract

Captopril, an orally active inhibitor of angiotensin converting enzyme, was administered for 12 months to 20 patients with mild or moderate esential hypertension who initially responded favourably to this pharmacological treatment. Captopril induced a significant reduction in blood pressure which remained unmodified throughout the study. This fall in blood pressure was mainly due to a significant decrease in total peripheral vascular resistance, since no change in cardiac ouput was observed. Simultaneously, there was no significant change in left ventricular anatomy and performance evaluated by echocardiographic technique.

Original languageEnglish
Pages (from-to)496-501
Number of pages6
JournalEuropean Heart Journal
Volume4
Issue number7
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

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