Haemodynamic effects of distension of the descending colon in anaesthetized dogs

A. Cevese, D. A S G Mary, R. Poltronieri, F. Schena, G. Vacca

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. This study was undertaken to determine whether distension of the descending colon in anaesthetized dogs reflexly affects the heart rate, arterial blood pressure or the left ventricular inotropic state. 2. Experiments were performed on twenty-six dogs, which were anaesthetized with sodium pentobarbitone and artificially ventilated. A segment of the distal descending colon was isolated and was distended with warm Ringer solution at a steady intraluminal pressure. 3. In each animal, distension of the colon caused an increase in heart rate and aortic blood pressure. The response of an increase in heart rate was augmented by preventing changes in aortic blood pressure, and was graded in seven dogs by step increments in the distending pressure. In the same animals, distension of the colon always caused a small increase in left ventricular (dP/dt)(max) at constant heart rate and aortic blood pressure. 4. In four of the twenty-six dogs, cutting the pelvic nerves did not abolish the observed responses to the distension. In seven of the twenty-six dogs, which included the four animals with sectioned pelvic nerves, cutting the hypogastric nerves completely abolished all the observed responses. 5. In thirteen of the twenty-six dogs, propranolol or bretylium tosylate completely abolished the reflex increases in heart rate and left ventricular (dP/dt)(max), and phentolamine or bretylium tosylate abolished the reflex increase in aortic blood pressure. 6. These results showed that distension of the colon reflexly increased the heart rate, arterial blood pressure and left ventricular inotropic state. These reflex responses were mediated by sympathetic effects and their afferent limb involved the hypogastric nerves.

Original languageEnglish
Pages (from-to)409-423
Number of pages15
JournalJournal of Physiology
Volume447
Publication statusPublished - 1992

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Descending Colon
Arterial Pressure
Heart Rate
Hemodynamics
Dogs
Bretylium Tosylate
Reflex
Colon
Pressure
Phentolamine
Pentobarbital
Propranolol
Extremities
Sodium

ASJC Scopus subject areas

  • Physiology

Cite this

Cevese, A., Mary, D. A. S. G., Poltronieri, R., Schena, F., & Vacca, G. (1992). Haemodynamic effects of distension of the descending colon in anaesthetized dogs. Journal of Physiology, 447, 409-423.

Haemodynamic effects of distension of the descending colon in anaesthetized dogs. / Cevese, A.; Mary, D. A S G; Poltronieri, R.; Schena, F.; Vacca, G.

In: Journal of Physiology, Vol. 447, 1992, p. 409-423.

Research output: Contribution to journalArticle

Cevese, A, Mary, DASG, Poltronieri, R, Schena, F & Vacca, G 1992, 'Haemodynamic effects of distension of the descending colon in anaesthetized dogs', Journal of Physiology, vol. 447, pp. 409-423.
Cevese, A. ; Mary, D. A S G ; Poltronieri, R. ; Schena, F. ; Vacca, G. / Haemodynamic effects of distension of the descending colon in anaesthetized dogs. In: Journal of Physiology. 1992 ; Vol. 447. pp. 409-423.
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