Haemodynamic predictors of a penetrating atherosclerotic ulcer rupture using fluid-structure interaction analysis

Giuseppe D'Ancona, Andrea Amaducci, Antonino Rinaudo, Salvatore Pasta, Fabrizio Follis, Michele Pilato, Roberto Baglini

Research output: Contribution to journalArticlepeer-review

Abstract

We present preliminary data on the flow-induced haemodynamic and structural loads exerted on a penetrating atherosclerotic aortic ulcer (PAU). Specifically, one-way fluid-structure interaction analysis was performed on the aortic model reconstructed from a 66-year-old male patient with a PAU that evolved into an intramural haematoma and rupture of the thoracic aorta. The results show that elevated blood pressure (117 mmHg) and low flow velocity at the aortic wall (0.15 m/s2) occurred in the region of the PAU. We also found a low value of time-averaged wall shear stress (1.24 N/m2) and a high value of the temporal oscillation in the wall shear stress (oscillatory shear index = 0.13) in the region of the PAU. After endovascular treatment, these haemodynamic parameters were distributed uniformly on the luminal surface of the stent graft. These findings suggest that wall shear stress could be considered one of the major haemodynamic factors indicating the structural fragility of the PAU wall, which ultimately lead to PAU growth and rupture.

Original languageEnglish
Pages (from-to)576-578
Number of pages3
JournalInteractive Cardiovascular and Thoracic Surgery
Volume17
Issue number3
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Fluid-structure interaction
  • Penetrating atherosclerotic ulcer
  • Wall shear stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

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