Haemodynamics, exercise capacity and clinical events in pulmonary arterial hypertension

Gianluigi Savarese, Francesca Musella, Carmen D́Amore, Teresa Losco, Caterina Marciano, Paola Gargiulo, Giuseppe Rengo, Santo Dellegrottaglie, Eduardo Bossone, Dario Leosco, Pasquale Perrone-Filardi

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to clarify whether changes in cardiopulmonary haemodynamics induced by pharmacological therapy correlate with exercise capacity and clinical events in patients with pulmonary arterial hypertension. 16 randomised trials including 2353 patients, followed up for 16.4±10.6 weeks, measuring cardiopulmonary haemodynamics by right heart catheterisation and reporting clinical events were included. Meta-analysis and meta-regression analysis were performed to assess the effects of treatments on clinical events and the relationship between haemodynamic changes (pulmonary artery pressure, pulmonary vascular resistance, cardiac index and right atrial pressure) and clinical events. Treatments significantly reduced all-cause death (OR 0.5, 95% CI 0.3́0.7; p

Original languageEnglish
Pages (from-to)414-424
Number of pages11
JournalEuropean Respiratory Journal
Volume42
Issue number2
DOIs
Publication statusPublished - Aug 1 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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