Haemostasis Contact System and Fibrinolysis in Hereditary Angioedema (Cl-Inhibitor Deficiency)

Massimo M. Cugno, L. Bergamaschini, L. Uziel, M. Cicardi, A. Agostoni, Annie F H Jie, C. Kluft

Research output: Contribution to journalArticle

Abstract

Factors of the classical complement pathway, the contact system and fibrinolysis were evaluated both with functional and immunochemical methods, in patients with inherited deficiency of Cl-inhibitor. Evaluations were performed under basal conditions, during acute attacks and during prophylaxis with low doses of anabolic steroids. Patients in the basal state showed no significant abnormalities of any of the parameters that we investigated. During acute attacks a slightly reduced prekallikrein concentration was registered. During treatment with low doses of danazol and stanozolol, protein C and plasminogen were found to be increased. Our data suggest that Cl-inhibitor deficiency per se does not lead to a derangement of the fibrinolysis and coagulation contact system, and that the kinin system may be involved during acute attacks of angioedema.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume26
Issue number7
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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