TY - JOUR
T1 - Haemostatic and fibrinolytic changes in obese subjects undergoing bariatric surgery
T2 - The effect of different surgical procedures
AU - Lupoli, Roberta
AU - Milone, Marco
AU - Di Minno, Alessandro
AU - Maietta, Paola
AU - Ambrosino, Pasquale
AU - Musella, Mario
AU - Di Minno, Matteo N D
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background. Little is known about effects of different bariatric surgery procedures on haemostatic and fibrinolytic parameters. Material and methods. Consecutive obese subjects undergoing gastric bypass (GBP) or sleeve gastrectomy (SG) were enrolled. In all patients, levels of haemostatic factors (FII, FVII, FVIII, FIX, FX, vWF, fibrinogen), fibrinolytic variables (PAI-1, t-PA and D-dimer) and natural anticoagulants (AT, protein C and protein S) were evaluated before and 2 months after surgery. Results. A total of 77 GBP and 79 SG subjects completed the study. At baseline no difference in coagulation parameters was found between the two groups. After both GBP and SG, subjects showed significant changes in haemostatic and fibrinolytic variables and in natural anticoagulant levels. The Δ% changes in FVII, FVIII, FIX, vWF, fibrinogen, D-dimer, protein C and protein S levels were significantly higher in subjects who underwent GBP than in those who underwent SG. Multivariate analysis confirmed that GBP was a predictor of higher Δ% changes in FVII (β=0.268, p=0.010), protein C (β=0.274, p=0.003) and protein S (β=0.297, p
AB - Background. Little is known about effects of different bariatric surgery procedures on haemostatic and fibrinolytic parameters. Material and methods. Consecutive obese subjects undergoing gastric bypass (GBP) or sleeve gastrectomy (SG) were enrolled. In all patients, levels of haemostatic factors (FII, FVII, FVIII, FIX, FX, vWF, fibrinogen), fibrinolytic variables (PAI-1, t-PA and D-dimer) and natural anticoagulants (AT, protein C and protein S) were evaluated before and 2 months after surgery. Results. A total of 77 GBP and 79 SG subjects completed the study. At baseline no difference in coagulation parameters was found between the two groups. After both GBP and SG, subjects showed significant changes in haemostatic and fibrinolytic variables and in natural anticoagulant levels. The Δ% changes in FVII, FVIII, FIX, vWF, fibrinogen, D-dimer, protein C and protein S levels were significantly higher in subjects who underwent GBP than in those who underwent SG. Multivariate analysis confirmed that GBP was a predictor of higher Δ% changes in FVII (β=0.268, p=0.010), protein C (β=0.274, p=0.003) and protein S (β=0.297, p
KW - Bariatric surgery
KW - Fibrinolysis
KW - Haemostasis
KW - Natural anticoagulants
KW - Obesity
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U2 - 10.2450/2014.0183-14
DO - 10.2450/2014.0183-14
M3 - Article
AN - SCOPUS:84946832422
VL - 13
SP - 442
EP - 447
JO - Blood Transfusion
JF - Blood Transfusion
SN - 1723-2007
IS - 3
ER -