Haemostatic gene polymorphisms in young Sardinian with acute myocardial infarction

Lorena Musino, Renata Rossi, Adolfo Partenza, Giovanna Mureddu, Angelo Zinellu, Patrizia Pilo, Ignazio Maoddi, Liana Spazzafumo, Flavia Franconi, Luca Deiana, Ciriaco Carru

Research output: Contribution to journalArticlepeer-review

Abstract

Although the role of environmental factors in the development of acute myocardial infarction (AMI) has been clearly established, the role of genetic factors is still undefined. The aim of this study was to investigate the association between various gene polymorphisms in the haemostatic system and the risk of myocardial infarction in a very genetic restricted area population of Sardinian young adults with AMI. The study case-control involved 71 patients who had survived a first MI at a mean age of 47,2 years and 150 healthy subjects. No differences in the allele or genotype frequencies were seen between the study groups for the fibrinogen, prothrombin, factor V, factor VII, vWF, TM, PAI-1, TPO gene, and PLA and HPA-2 genes polymorphisms. Indeed differences statistically significant were detected for A5709G in the TPO gene (P= 0,041), and I/D dimorphism in the eNOS gene (P= 0,016). We therefore conclude that among all the investigated polymorphisms only the 5709G and eNOS4a alleles seem to confer protection against MI in the young age of Sardinian people.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number2
Publication statusPublished - Jan 1 2010

Keywords

  • Coagulation
  • Fibrinolysis
  • Genetic polymorphism
  • Myocardial infarction
  • Platelets
  • Young

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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