Emovigilanza in un SIMT pediatrico: Reazioni avverse alla terapia trasfusionale segnalate nel periodo 2001-2003

Translated title of the contribution: Haemovigilance in a paediatric SIMT: Adverse reactions to transfusion therapy in the period 2001-2003

Marina Martinengo, Diego Ardenghi, Gino Tripodi

Research output: Contribution to journalArticle

Abstract

Background. This study analyses the data on transfusion reactions occurring in the period between 2001-2003 in the "Giannina Gaslini" Institute. The aim of the study was to verify whether the Haemovigilance System, adopted in our SIMT as a tool to control the adverse effects of transfusions, is suitable and whether the information derived could indicate strategies for improving the various operative procedures. Materials and methods. The data were collected using a card accompanying the blood component to record peritransfusional reactions, and a form to notify any late adverse effects. Statistical analyses were carried out on these data examining the type of patient and the period of the transfusion. In this way we evaluated the frequency and the type of adverse reactions, correlating them with the immunohaematological profile of the patient and with the ways the blood components had been produced. Results. The analysis showed that there was a higher frequency of transfusion reactions after platelet transfusions than after administration of red cell concentrates. The reactions to the platelet concentrates were mostly urticarial-type side effects, while febrile reactions were more common after transfusions of red cell concentrates. It was found that the adverse reactions were not correlated with the method of collecting or manipulating the blood components, but were observed particularly in multiply transfused patients: this explains the prevalence of urticarial signs as a typical allergic reaction to plasma proteins in such patients. Furthermore, the peak occurrence of transfusion reactions corresponded to the high prevalences of multiply transfused subjects in these periods. The system for reporting adverse reactions to transfusional support seems to be adequate for the peri-transfusional events, while the collection of medium to long-term data needs further organizational refinement. Conclusions. The number of transfusion reactions reported in the period considered was not lower than the number in the period before adopting the Haemovigilance System; the usefulness of the System lies in rapid modification of the transfusional support in the case of adverse events.

Translated title of the contributionHaemovigilance in a paediatric SIMT: Adverse reactions to transfusion therapy in the period 2001-2003
Original languageItalian
Pages (from-to)218-230
Number of pages13
JournalBlood Transfusion
Volume2
Issue number3
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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