Halitosis and Helicobacter pylori: A possible relationship

Enzo Ierardi, Annacinzia Amoruso, Teresa La Notte, Ruggiero Francavilla, Stefania Castellaneta, Elisa Marrazza, Rosa Anna Monno, Antonio Francavilla

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

With the aim of investigating a possible relationship between 'objective' halitosis (established by sulfide levels in the breath) and Helicobacter pylori, we performed a study in 58 dyspeptic patients reported to suffer from 'bad breath.' Furthermore, we evaluated the effects on halitosis of eradication therapy (only for H. pylori-positive patients) and chlorhexidine antiseptic mouth rinses (in all patients). Sulfide compound assay indicated objective halitosis in 52/58 patients, 30 of whom were positive and 22 negative for H. pylori. In 19/30 eradication by double therapy provoked a decrease to below the cutoff value of sulfide levels in 15. In the other 11 of the 30 subjects, in whom H. pylori positivity persisted, halitosis parameters did not change. Chlorexidine reduced sulfides to below the cutoff value in 16/22 H. pylori-negative patients, but did not provoke any change in the 11 unsuccessfully treated H. pylori-positive subjects. In these, objective halitosis disappeared only after a successful eradication by triple therapy (9/11). Our results show a possible association between halitosis and H. pylori since bacterial eradication may resolve the symptom. Antiseptic mouthwashes may be effective only in absence of H. pylori, when halitosis may be due to oral putrefactive microbial activity. In a small number of subjects the cause and treatment of halitosis need to be clarified.

Original languageEnglish
Pages (from-to)2733-2737
Number of pages5
JournalDigestive Diseases and Sciences
Volume43
Issue number12
DOIs
Publication statusPublished - 1998

Fingerprint

Halitosis
Helicobacter pylori
Sulfides
Local Anti-Infective Agents
Mouthwashes
Chlorhexidine
Therapeutics
Mouth

Keywords

  • Bad breath
  • Dyspepsia
  • Halitosis
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ierardi, E., Amoruso, A., La Notte, T., Francavilla, R., Castellaneta, S., Marrazza, E., ... Francavilla, A. (1998). Halitosis and Helicobacter pylori: A possible relationship. Digestive Diseases and Sciences, 43(12), 2733-2737. https://doi.org/10.1023/A:1026619831442

Halitosis and Helicobacter pylori : A possible relationship. / Ierardi, Enzo; Amoruso, Annacinzia; La Notte, Teresa; Francavilla, Ruggiero; Castellaneta, Stefania; Marrazza, Elisa; Monno, Rosa Anna; Francavilla, Antonio.

In: Digestive Diseases and Sciences, Vol. 43, No. 12, 1998, p. 2733-2737.

Research output: Contribution to journalArticle

Ierardi, E, Amoruso, A, La Notte, T, Francavilla, R, Castellaneta, S, Marrazza, E, Monno, RA & Francavilla, A 1998, 'Halitosis and Helicobacter pylori: A possible relationship', Digestive Diseases and Sciences, vol. 43, no. 12, pp. 2733-2737. https://doi.org/10.1023/A:1026619831442
Ierardi E, Amoruso A, La Notte T, Francavilla R, Castellaneta S, Marrazza E et al. Halitosis and Helicobacter pylori: A possible relationship. Digestive Diseases and Sciences. 1998;43(12):2733-2737. https://doi.org/10.1023/A:1026619831442
Ierardi, Enzo ; Amoruso, Annacinzia ; La Notte, Teresa ; Francavilla, Ruggiero ; Castellaneta, Stefania ; Marrazza, Elisa ; Monno, Rosa Anna ; Francavilla, Antonio. / Halitosis and Helicobacter pylori : A possible relationship. In: Digestive Diseases and Sciences. 1998 ; Vol. 43, No. 12. pp. 2733-2737.
@article{ee9b293cea67461ea06166eae5650caa,
title = "Halitosis and Helicobacter pylori: A possible relationship",
abstract = "With the aim of investigating a possible relationship between 'objective' halitosis (established by sulfide levels in the breath) and Helicobacter pylori, we performed a study in 58 dyspeptic patients reported to suffer from 'bad breath.' Furthermore, we evaluated the effects on halitosis of eradication therapy (only for H. pylori-positive patients) and chlorhexidine antiseptic mouth rinses (in all patients). Sulfide compound assay indicated objective halitosis in 52/58 patients, 30 of whom were positive and 22 negative for H. pylori. In 19/30 eradication by double therapy provoked a decrease to below the cutoff value of sulfide levels in 15. In the other 11 of the 30 subjects, in whom H. pylori positivity persisted, halitosis parameters did not change. Chlorexidine reduced sulfides to below the cutoff value in 16/22 H. pylori-negative patients, but did not provoke any change in the 11 unsuccessfully treated H. pylori-positive subjects. In these, objective halitosis disappeared only after a successful eradication by triple therapy (9/11). Our results show a possible association between halitosis and H. pylori since bacterial eradication may resolve the symptom. Antiseptic mouthwashes may be effective only in absence of H. pylori, when halitosis may be due to oral putrefactive microbial activity. In a small number of subjects the cause and treatment of halitosis need to be clarified.",
keywords = "Bad breath, Dyspepsia, Halitosis, Helicobacter pylori",
author = "Enzo Ierardi and Annacinzia Amoruso and {La Notte}, Teresa and Ruggiero Francavilla and Stefania Castellaneta and Elisa Marrazza and Monno, {Rosa Anna} and Antonio Francavilla",
year = "1998",
doi = "10.1023/A:1026619831442",
language = "English",
volume = "43",
pages = "2733--2737",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Halitosis and Helicobacter pylori

T2 - A possible relationship

AU - Ierardi, Enzo

AU - Amoruso, Annacinzia

AU - La Notte, Teresa

AU - Francavilla, Ruggiero

AU - Castellaneta, Stefania

AU - Marrazza, Elisa

AU - Monno, Rosa Anna

AU - Francavilla, Antonio

PY - 1998

Y1 - 1998

N2 - With the aim of investigating a possible relationship between 'objective' halitosis (established by sulfide levels in the breath) and Helicobacter pylori, we performed a study in 58 dyspeptic patients reported to suffer from 'bad breath.' Furthermore, we evaluated the effects on halitosis of eradication therapy (only for H. pylori-positive patients) and chlorhexidine antiseptic mouth rinses (in all patients). Sulfide compound assay indicated objective halitosis in 52/58 patients, 30 of whom were positive and 22 negative for H. pylori. In 19/30 eradication by double therapy provoked a decrease to below the cutoff value of sulfide levels in 15. In the other 11 of the 30 subjects, in whom H. pylori positivity persisted, halitosis parameters did not change. Chlorexidine reduced sulfides to below the cutoff value in 16/22 H. pylori-negative patients, but did not provoke any change in the 11 unsuccessfully treated H. pylori-positive subjects. In these, objective halitosis disappeared only after a successful eradication by triple therapy (9/11). Our results show a possible association between halitosis and H. pylori since bacterial eradication may resolve the symptom. Antiseptic mouthwashes may be effective only in absence of H. pylori, when halitosis may be due to oral putrefactive microbial activity. In a small number of subjects the cause and treatment of halitosis need to be clarified.

AB - With the aim of investigating a possible relationship between 'objective' halitosis (established by sulfide levels in the breath) and Helicobacter pylori, we performed a study in 58 dyspeptic patients reported to suffer from 'bad breath.' Furthermore, we evaluated the effects on halitosis of eradication therapy (only for H. pylori-positive patients) and chlorhexidine antiseptic mouth rinses (in all patients). Sulfide compound assay indicated objective halitosis in 52/58 patients, 30 of whom were positive and 22 negative for H. pylori. In 19/30 eradication by double therapy provoked a decrease to below the cutoff value of sulfide levels in 15. In the other 11 of the 30 subjects, in whom H. pylori positivity persisted, halitosis parameters did not change. Chlorexidine reduced sulfides to below the cutoff value in 16/22 H. pylori-negative patients, but did not provoke any change in the 11 unsuccessfully treated H. pylori-positive subjects. In these, objective halitosis disappeared only after a successful eradication by triple therapy (9/11). Our results show a possible association between halitosis and H. pylori since bacterial eradication may resolve the symptom. Antiseptic mouthwashes may be effective only in absence of H. pylori, when halitosis may be due to oral putrefactive microbial activity. In a small number of subjects the cause and treatment of halitosis need to be clarified.

KW - Bad breath

KW - Dyspepsia

KW - Halitosis

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=0032440473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032440473&partnerID=8YFLogxK

U2 - 10.1023/A:1026619831442

DO - 10.1023/A:1026619831442

M3 - Article

C2 - 9881507

AN - SCOPUS:0032440473

VL - 43

SP - 2733

EP - 2737

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 12

ER -