Haloperidol administration in humans lowers plasma nerve growth factor level: Evidence that sedation induces opposite effects to arousal

Luigi Aloe, Angela Iannitelli, Giuseppe Bersani, Enrico Alleva, Francesco Angelucci, Paolo Maselli, Luigi Manni

Research output: Contribution to journalArticle

Abstract

Studies reported in recent years have indicated that the level of nerve growth factor (NGF), in both the brain and in the bloodstream, increases following stressful events and anxiety-associated behaviour. These observations prompted us to investigate whether an anti-arousal drug would induce an opposite effect. We have reported that the administration of haloperidol (HA), a neuroleptic drug clinically used for psychiatric disorders, decreases NGF levels in the hypothalamus of adult male mice. In the present study, we showed that HA reduced the basal NGF plasma levels in 8 neuroleptic-free schizophrenic patients. These observations strengthen the hypothesis that NGF may play a functional role in stress-coping responses.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalNeuropsychobiology
Volume36
Issue number2
Publication statusPublished - Aug 1997

Keywords

  • Arousal
  • Haloperidol
  • Nerve growth factor
  • Schizophrenia
  • Sedation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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    Aloe, L., Iannitelli, A., Bersani, G., Alleva, E., Angelucci, F., Maselli, P., & Manni, L. (1997). Haloperidol administration in humans lowers plasma nerve growth factor level: Evidence that sedation induces opposite effects to arousal. Neuropsychobiology, 36(2), 65-68.