Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4

Federica Ginanneschi, Maria A. Carluccio, Andrea Mignarri, Alessandra Tessa, Filippo M. Santorelli, Alessandro Rossi, Antonio Federico, Maria T. Dotti

Research output: Contribution to journalArticle

Abstract

Transcranial magnetic stimulation (TMS) studies on the pathways to the upper limbs have revealed inconsistent results in patients harboring mutations in SPAST/SPG4 gene, responsible for the commonest form of hereditary spastic paraplegia (HSP). This paper is addressed to study the corticomotor excitability of the pathways to the upper limbs in SPG4 subjects. We assessed the corticomotor excitability of hand muscles in 12 subjects belonging to 7 unrelated SPG4 families and in 12 control subjects by stimulus-response curve [input-output (I-O) curve]. All the parameters of the recruitment curve (threshold, V50, slope and plateau) did not differ significantly from those of the controls. Presence of upper limb hyper-reflexia did not influence the results of I-O curve. Considering the multiplicity of possible genes/loci accounting for pure HSPs, performing TMS analyses could be helpful in differential diagnosis of pure HSPs in the absence of other clinical or neuroimaging tools.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalNeurological Sciences
Volume35
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Spastic Paraparesis
Upper Extremity
Transcranial Magnetic Stimulation
Hand
Muscles
Hereditary Spastic Paraplegia
Neuroimaging
Genes
Differential Diagnosis
Mutation

Keywords

  • Brain stimulation
  • Hereditary spastic paraplegia
  • Input-output curve

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

Cite this

Ginanneschi, F., Carluccio, M. A., Mignarri, A., Tessa, A., Santorelli, F. M., Rossi, A., ... Dotti, M. T. (2014). Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4. Neurological Sciences, 35(8), 1287-1291. https://doi.org/10.1007/s10072-014-1707-7

Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4. / Ginanneschi, Federica; Carluccio, Maria A.; Mignarri, Andrea; Tessa, Alessandra; Santorelli, Filippo M.; Rossi, Alessandro; Federico, Antonio; Dotti, Maria T.

In: Neurological Sciences, Vol. 35, No. 8, 2014, p. 1287-1291.

Research output: Contribution to journalArticle

Ginanneschi, F, Carluccio, MA, Mignarri, A, Tessa, A, Santorelli, FM, Rossi, A, Federico, A & Dotti, MT 2014, 'Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4', Neurological Sciences, vol. 35, no. 8, pp. 1287-1291. https://doi.org/10.1007/s10072-014-1707-7
Ginanneschi, Federica ; Carluccio, Maria A. ; Mignarri, Andrea ; Tessa, Alessandra ; Santorelli, Filippo M. ; Rossi, Alessandro ; Federico, Antonio ; Dotti, Maria T. / Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4. In: Neurological Sciences. 2014 ; Vol. 35, No. 8. pp. 1287-1291.
@article{779f0d53eaca41a3a2f6b2c716fb0818,
title = "Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4",
abstract = "Transcranial magnetic stimulation (TMS) studies on the pathways to the upper limbs have revealed inconsistent results in patients harboring mutations in SPAST/SPG4 gene, responsible for the commonest form of hereditary spastic paraplegia (HSP). This paper is addressed to study the corticomotor excitability of the pathways to the upper limbs in SPG4 subjects. We assessed the corticomotor excitability of hand muscles in 12 subjects belonging to 7 unrelated SPG4 families and in 12 control subjects by stimulus-response curve [input-output (I-O) curve]. All the parameters of the recruitment curve (threshold, V50, slope and plateau) did not differ significantly from those of the controls. Presence of upper limb hyper-reflexia did not influence the results of I-O curve. Considering the multiplicity of possible genes/loci accounting for pure HSPs, performing TMS analyses could be helpful in differential diagnosis of pure HSPs in the absence of other clinical or neuroimaging tools.",
keywords = "Brain stimulation, Hereditary spastic paraplegia, Input-output curve",
author = "Federica Ginanneschi and Carluccio, {Maria A.} and Andrea Mignarri and Alessandra Tessa and Santorelli, {Filippo M.} and Alessandro Rossi and Antonio Federico and Dotti, {Maria T.}",
year = "2014",
doi = "10.1007/s10072-014-1707-7",
language = "English",
volume = "35",
pages = "1287--1291",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "8",

}

TY - JOUR

T1 - Hand muscles corticomotor excitability in hereditary spastic paraparesis type 4

AU - Ginanneschi, Federica

AU - Carluccio, Maria A.

AU - Mignarri, Andrea

AU - Tessa, Alessandra

AU - Santorelli, Filippo M.

AU - Rossi, Alessandro

AU - Federico, Antonio

AU - Dotti, Maria T.

PY - 2014

Y1 - 2014

N2 - Transcranial magnetic stimulation (TMS) studies on the pathways to the upper limbs have revealed inconsistent results in patients harboring mutations in SPAST/SPG4 gene, responsible for the commonest form of hereditary spastic paraplegia (HSP). This paper is addressed to study the corticomotor excitability of the pathways to the upper limbs in SPG4 subjects. We assessed the corticomotor excitability of hand muscles in 12 subjects belonging to 7 unrelated SPG4 families and in 12 control subjects by stimulus-response curve [input-output (I-O) curve]. All the parameters of the recruitment curve (threshold, V50, slope and plateau) did not differ significantly from those of the controls. Presence of upper limb hyper-reflexia did not influence the results of I-O curve. Considering the multiplicity of possible genes/loci accounting for pure HSPs, performing TMS analyses could be helpful in differential diagnosis of pure HSPs in the absence of other clinical or neuroimaging tools.

AB - Transcranial magnetic stimulation (TMS) studies on the pathways to the upper limbs have revealed inconsistent results in patients harboring mutations in SPAST/SPG4 gene, responsible for the commonest form of hereditary spastic paraplegia (HSP). This paper is addressed to study the corticomotor excitability of the pathways to the upper limbs in SPG4 subjects. We assessed the corticomotor excitability of hand muscles in 12 subjects belonging to 7 unrelated SPG4 families and in 12 control subjects by stimulus-response curve [input-output (I-O) curve]. All the parameters of the recruitment curve (threshold, V50, slope and plateau) did not differ significantly from those of the controls. Presence of upper limb hyper-reflexia did not influence the results of I-O curve. Considering the multiplicity of possible genes/loci accounting for pure HSPs, performing TMS analyses could be helpful in differential diagnosis of pure HSPs in the absence of other clinical or neuroimaging tools.

KW - Brain stimulation

KW - Hereditary spastic paraplegia

KW - Input-output curve

UR - http://www.scopus.com/inward/record.url?scp=84905090363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905090363&partnerID=8YFLogxK

U2 - 10.1007/s10072-014-1707-7

DO - 10.1007/s10072-014-1707-7

M3 - Article

C2 - 24648003

AN - SCOPUS:84905090363

VL - 35

SP - 1287

EP - 1291

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 8

ER -