Handedness effects on interhemispheric transfer time: A TMS study

Demis Basso, Tomaso Vecchi, Lilach Akiva Kabiri, Ilaria Baschenis, Elisa Boggiani, Patrizia S. Bisiacchi

Research output: Contribution to journalArticlepeer-review


The crossed-uncrossed difference (CUD) estimates the interhemispheric transfer time (ITT) through the corpus callosum. Previous research has shown that transcranial magnetic stimulation (TMS) to the occipital cortex determines an increased CUD during cognitive tasks. The aim of the present study was to investigate whether TMS stimulation applied at a motor stage can interfere with the ITT, comparing the performance of left- and right-handed people. Results showed a significant TMS effect, i.e. increasing reaction times were reported when stimulation was delivered on the left primary motor area. Effects were more evident when information was primarily perceived through the dominant hemisphere. Both left and right stimulations increased CUD times in right-handed subjects; however, left-handed subjects showed significant effects associated with left stimulation only. Furthermore, in both groups, TMS produced larger effects in the crossed than in the uncrossed condition. TMS stimulation increased reaction times, thus supporting the idea that the interhemispheric transfer of visuo-motor information occurs at a motor processing stage. The dominant hemisphere seems to play a major role within this process: our data indicates that left- and right-handed people have different ITT latencies associated with the transfer of information to the contralateral hemisphere.

Original languageEnglish
Pages (from-to)228-232
Number of pages5
JournalBrain Research Bulletin
Issue number3
Publication statusPublished - Jul 31 2006


  • Crossed-uncrossed difference
  • Interhemispheric transfer time
  • Motor cortex
  • Reaction times
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)


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