Handling of retroviral antigens by human antigen-presenting cells

D. Fenoglio, G. Li Pira, D. Saverino, A. Ferraris, F. Lancia, A. Megiovanni, L. Oppezzi, G. Piatti, F. Buffa, M. T. Valle, A. Kunkl, F. Manca

Research output: Contribution to journalArticle

Abstract

Antigen-specific T helper cells play an important role in retroviral infections. Indeed, they provide help for B-cell activation and antibody production and for clonal expansion of cytolytic lymphocytes. Therefore, we used retrovirus-specific human T helper clones in order to define modes of antigen presentation, antigen-presenting cells and the molecular context of Th epitopes that could be exploited in the design of immunogens aimed at optimizing the Th cell response. In particular, we describe several mechanisms of receptor-mediated antigen uptake that enhance the stimulation of human T-cell clones specific for HIV and HTLV-1 antigens; we report on the differential recognition of Th epitopes depending on the molecular-viral context; we show that dendritic cells are the most efficient presenting cells and are essential for the induction of in vitro primary Th cell responses; and finally, we propose that Th cells specific for internal, conserved antigens of HIV such as reverse transcriptase, may be candidates for intrastructural help resulting in induction of envelope specific antibodies.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalResearch in Virology
Volume147
Issue number2-3
DOIs
Publication statusPublished - Mar 1996

Fingerprint

Antigen-Presenting Cells
Antigens
Deltaretrovirus Antigens
Epitopes
Clone Cells
HIV Antigens
Antigen Receptors
Human T-lymphotropic virus 1
RNA-Directed DNA Polymerase
Antigen Presentation
Retroviridae
Helper-Inducer T-Lymphocytes
Dendritic Cells
Antibody Formation
HIV-1
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Antibodies
Infection

Keywords

  • APC
  • Gp120
  • HIV
  • HTLV-1
  • Human T clones
  • Immunogenicity
  • Intrastructural help
  • Molecular context
  • P66
  • Retroviral antigens
  • T lymphocyte

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Handling of retroviral antigens by human antigen-presenting cells. / Fenoglio, D.; Li Pira, G.; Saverino, D.; Ferraris, A.; Lancia, F.; Megiovanni, A.; Oppezzi, L.; Piatti, G.; Buffa, F.; Valle, M. T.; Kunkl, A.; Manca, F.

In: Research in Virology, Vol. 147, No. 2-3, 03.1996, p. 97-101.

Research output: Contribution to journalArticle

Fenoglio, D, Li Pira, G, Saverino, D, Ferraris, A, Lancia, F, Megiovanni, A, Oppezzi, L, Piatti, G, Buffa, F, Valle, MT, Kunkl, A & Manca, F 1996, 'Handling of retroviral antigens by human antigen-presenting cells', Research in Virology, vol. 147, no. 2-3, pp. 97-101. https://doi.org/10.1016/0923-2516(96)80222-6
Fenoglio, D. ; Li Pira, G. ; Saverino, D. ; Ferraris, A. ; Lancia, F. ; Megiovanni, A. ; Oppezzi, L. ; Piatti, G. ; Buffa, F. ; Valle, M. T. ; Kunkl, A. ; Manca, F. / Handling of retroviral antigens by human antigen-presenting cells. In: Research in Virology. 1996 ; Vol. 147, No. 2-3. pp. 97-101.
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