Haploidentical transplantation in patients with acquired aplastic anemia

F. Ciceri, M. T. Lupo-Stanghellini, E. T. Korthof

Research output: Contribution to journalArticlepeer-review

Abstract

Haploidentical SCT (haplo-SCT) has been considered a therapeutic option in patients with acquired severe aplastic anemia (SAA) failing at least one course of immune suppressive therapy with antithymocyte globulin and lacking an HLA-matched related or unrelated donor. The platforms of both ex vivo T-cell-depleted and unmanipulated grafts have been explored in children and adults. Overall, the primary objective of a stable haploidentical hematopoietic engraftment with a low rate of GVHD is unmet in a significant proportion of patients undergoing haplo-SCT for SAA. Haploidentical transplants for refractory SAA should be performed in a specialist center with major experience in hematopoietic SCT procedures and preferably performed within the framework of a local clinical protocol designed specifically to address the prevention of graft rejection and GVHD.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalBone Marrow Transplantation
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • aplastic anemia
  • ATG
  • haploidentical

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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