Haploinsufficiency for tumour suppressor genes: When you don't need to go all the way

Manuela Santarosa, Alan Ashworth

Research output: Contribution to journalArticlepeer-review

Abstract

Classical tumour suppressor genes are thought to require mutation or loss of both alleles to facilitate tumour progression. However, it has become clear over the last few years that for some genes, haploinsufficiency, which is loss of only one allele, may contribute to carcinogenesis. These effects can either be directly attributable to the reduction in gene dosage or may act in concert with other oncogenic or haploinsufficient events. Here we describe the genes that undergo this phenomenon and discuss possible mechanisms that allow haploinsufficiency to display a phenotype and facilitate the pathogenesis of cancer.

Original languageEnglish
Pages (from-to)105-122
Number of pages18
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1654
Issue number2
DOIs
Publication statusPublished - Jun 7 2004

Keywords

  • Breast cancer
  • Calorectal cancer
  • Haploinsufficiency
  • Leukemia
  • Mutation
  • Prostate cancer
  • Tumour suppressor gene

ASJC Scopus subject areas

  • Biophysics
  • Cancer Research
  • Oncology

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